摘要
EB病毒(EBV)在感染宿主的过程中需要克服宿主免疫系统的防御,因此衍生了一系列干扰人体免疫的策略。EBV感染后会长期潜伏在宿主B细胞中,并对宿主主要组织相容性复合体分子的表达进行干扰,影响宿主的抗病毒免疫。EBV表达的BCRF1蛋白可刺激Th2细胞的产生,BARF1蛋白可诱发α型干扰素等细胞因子的分泌,多种病毒蛋白均可干扰细胞因子网络。同时EBV编码的BHRF1等蛋白可发挥抗凋亡作用。该文就EBV免疫逃避的最新研究进展进行了归纳总结,以期为EBV防控、新型疫苗设计等提供参考。
In order to resist the defense from the host immune system in the infection process,EB virus（ EBV） has to produce a series of interference strategies against human immune system. EBV can latent in the B cells of host for a long term after infection and interfere the expression of host MHC to affect the host immune system. EBV BCRF1 protein can induce the creation of Th2 cells,and BARF1 protein can induce the secretion of interferon-α. Many viral proteins could interfere in the cytokine network. Besides,BHRF1 protein encoded by EBV may play an anti-apoptotic role in the host body. Here is to make a review of latest research progress on the mechanisms of EBV in evading the host immune in order to provide reference for EBV prevention and control as well as the design of new vaccines.
出处
《医学综述》
2015年第3期417-420,共4页
Medical Recapitulate
关键词
EB病毒
免疫逃逸
宿主免疫
Epstein-Barr virus
Immune escape
Host immune
