脑-肠肽与胃食管反流病关系的研究进展

Research Progress on the Relationship Between Brain Gut Peptide and Gastroesophageal Reflux Disease

胃食管反流病(GERD)的发病机制尚不明确,近年来研究表明脑-肠肽在其发生、发展过程中起重要作用。在GERD患者中脑-肠肽通过各种不同的机制,对于食管下段括约肌有一定的调节作用,从而参与了GERD的发生,对于各种脑-肠肽在GERD中的发病机制的研究,可能对于GERD的治疗和预后有着重要的意义。将脑-肠肽作为一个新的靶点,也必将给GERD患者的治疗提供新的方向。

Although the pathogenesis of gastroesophageal reflux disease still remains unclear,recent studies have shown that brain gut peptides play an important role in the incidence and progression of gastroesophageal reflux disease. In patients with gastroesophageal reflux disease,brain gut peptide has a regulatory role on the lower esophageal sphincter through different mechanisms,thus involves in the incidence of gastroesophageal reflux disease. Studies on the role of various brain gut peptides in the pathogenesis of gastroesophageal reflux disease may have great significance in the treatment and prognosis of gastrioesophageal reflux disease. The brain gut peptide,as a new target,would also provide a new direction of the treatment for gastroesophageal reflux disease.