心脏再同步治疗应答反应探讨

Discussion on the Effects of Cardiac Resynchronization Therapy in Treating Cardiovascular Diseases

心脏再同步治疗(CRT)在心力衰竭治疗方面的效果已被广泛证实。随着指南的更新,其治疗的适应证范围不断扩大,更多患者将从中受益。但研究证明,仍有近30%的患者表现为CRT无应答。由于目前还没有统一的、被普遍认可的CRT应答评估标准,CRT治疗效果的评价仍较为混乱。越来越多的研究致力于提高CRT应答率,以更好地预测患者的预后,帮助临床决策。该文试图通过分析总结目前有关CRT无应答的原因,探寻最优的应答评估标准和更好的引导程控优化的方法,为提高CRT应答率提供参考依据。

The effects of cardiac resynchronization therapy（ CRT） in the treatment for heart failure have been widely confirmed. As the guideline updates,indication range of CRT has been expanded,which will benefit more patients. But some studies have shown that there are still nearly 30% of the patients having no response to CRT. Because there has not been any generally accepted CRT response evaluation standard,the evaluation on the effect of CRT treatment is still relatively confused. Therefore,more and more researches have been committed to increase the CRT response rate in order to improve the prognosis. Here is to make a review of the recent research findings of the reasons for no response to CRT,so as to provide reference for finding the optimal response assessment criteria and better control method after operation,and improve the Cardiac resynchronization therapy response rate.