子痫前期发病机制的研究进展

Research Advances in Pathogenesis of Pre-eclampsia

子痫前期是妊娠特有的疾病,由于该病对母儿的危害极大,其发病机制一直是产科研究的焦点。随着研究的不断深入,目前认为该病主要与遗传、血管内皮受损、免疫失衡及炎症反应等因素相关,其中遗传因素是内因,血管内皮损伤因子水平异常升高、血管内皮保护因子水平降低是该病发生、发展的关键环节,而免疫失衡及炎症反应进一步加重血管内皮的损伤,多种机制相互作用导致子痫前期的发生。

Pre-eclampsia is a specific disease during pregnancy. Due to its great harm to mothers and fetus,study on the pathogenesis of the disease has always been the focus in obstetrics. Along with the deepening research of the disease,it has been considered that the disease is correlated with the factors of heredity,vascular endothelium injuries,immune imbalances and inflammatory reaction,etc. Among all those factors,hereditary is the internal cause,abnormal rising of vascular endothelium damage factor levels and decreasing of vascular endothelium protection factor levels are the key steps of disease development,besides,immune imbalances and inflammatory reactions further aggravate the vascular endothelium injuries,interaction of multiple mechanisms mentioned above lead to the disease.