红细胞分布宽度在常见心血管疾病诊疗中的应用进展

Clinical Application and Progress of Red Blood Cell Distribution Width in the Diagnosis and Treatment of Common Cardiovascular Diseases

红细胞分布宽度(RDW)既往主要用于贫血的诊断和分类。近年来研究发现,RDW在高血压、冠状动脉粥样硬化性心脏病(冠心病)、急慢性心力衰竭、肺动脉高压及非选择性人群中均有不同程度的升高,且与病情轻重呈正相关,RDW升高对该组疾病的预后有独立预测作用。目前其确切作用机制尚未明确,主要与营养不良、神经内分泌系统激活、炎性反应、肾功能不全、肝淤血、肝功能障碍有关。但RDW不是特异性指标,间接反映了患者病情较重、一般情况差,故可用于估计病情和预后。

Red blood cell distribution width（ RDW） was mainly used in diagnosing and classifying of anemia in the past. Resent studies revealed that RDW elevates at different levels in the patients with hypertension,coronary heart diseases,acute or chronic heart failure,pulmonary artery hypertension and in the nonselective population,which is positively related to the severity of the disease condition,therefore elevated RDW can independently predict the prognosis of this group of diseases. However,the exact mechanisms need further studies and elevated RDW is mainly relative with malnutrition,activation of the neuroendocrine system,inflammatory reaction,renal failure,hepatic congestion and dysfunction. But RDW is not a specific indicator,and it indirectly reflects a serious illness condition and poor general condition,which can be used to evaluate the condition and estimate the prognosis.