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嘌呤受体:缓解阿片耐受的一个潜在靶点 被引量：1

Purinoceptor: the Potential Therapeutic Target for Opioid Tolerance
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摘要 神经胶质细胞在阿片类药耐受的发生和维持中发挥着重要的作用。胶质细胞上嘌呤受体的激活可诱导其合成和释放促炎因子、神经活性物质等,参与神经病理性疼痛及阿片耐受的形成和维持。靶向抑制嘌呤受体的各种亚型在神经病理性疼痛和阿片耐受的研究中已取得初步进展,其可能成为缓解阿片耐受的重要治疗靶点。因此,理解嘌呤受体的结构和生物学功能可能为临床治疗阿片耐受提供新的选择。 Gliocyte plays a crucial role in the development and maintenance of tolerance to opioid analgesia. Purinoceptor activation on glial cells can induce the synthesis and release of proinflammatory cytokines and neuroactive substances,which are involved in the development and maintenance of the neuropathy pain and opioid tolerance. Targeting inhibition of purinoceptor subtypes in neuropathic pain and opioid tolerance has made preliminary progress,therefore,purinoceptor may become the important therapeutic targets to alleviate opioid tolerance. Therefore,understanding of the structure and biological function of purinoceptor may provide a new choice for the clinical treatment of morphine tolerance.
作者 周宁 李伟彦
机构地区 南京军区南京总医院麻醉科
出处 《医学综述》 2015年第4期693-695,共3页 Medical Recapitulate
关键词 嘌呤受体 阿片耐受 胶质细胞 Purinoceptor Opioid tolerance Gliocyte
分类号 R441.1 [医药卫生—诊断学]
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参考文献29

  • 1赵鹤,梁语丝,单风平.阿片物质对免疫系统的作用[J].医学综述,2012,18(7):989-991. 被引量：9
  • 2Martini L, Whistler JL. The role of mu opioid receptor desensitiza- tion and endocytosis in morphine tolerance and dependence [J ]. Curt Opin Neurobio1,2007,17 (5) :556-564.
  • 3Abbracchio MP, Burnstock G, Boeynaems JM, et al. International Union of Pharmacology L/:update on the P2Y G protein-coupled nucleotide receptors:from molecular mechanisms and pathophysiol- ogy to therapy [ J ] Pharmacol Rev ,2006,58 ( 3 ) :281-341.
  • 4Burnstock G. Purinergic signalling : past, present and future [ J ]. Braz J Med Biol Res,2009,42(1 ) :3-8.
  • 5Khakh BS,Burnstock G, Kennedy C, et al. International union of pharmacology. XXIV. Current status of the' nomenclature and prop- erties of P2X receptors and their subunits [ J]. Pharmacol Rev, 2001,53( 1 ) :107-118.
  • 6North RA. Molecular physiology of P2X receptors [ J ]. Pharmacol Rev,2002,82(4) : 1013-1067.
  • 7Vial C, Roberts JA, Evans RJ. Molecular properties of Nl'P-gated P2X receptor ion channels [ J ]. Trends Pharmacol Sci, 2004,25 (9) :487-493.
  • 8Jarvis MF,Khakh BS, ATP-gated P2X cation-channels [J]. Neuro- pharmacology ,2009,56 ( 1 ) :208-215.
  • 9Horvath RJ, Romero-Sandoval EA, Leo JAD. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Ibal, GFAP and opioid receptor protein expression while enhancing perivascular microglial ED2 [ J ]. Pain ,2010,150 ( 3 ) :401-413.
  • 10Tsuda M,Shigemoto-Mogami Y, Koizumi S, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury [J]. Nature ,2003,424 (6950) :778-783.

二级参考文献23

  • 1Benyamin R,Trescot AM,Datta S,et al.Opioid complications andside effects[J].Pain Physician,2008,11(2):S105-S120.
  • 2Martin JL,Charboneau R,Barke RA,et al.Chronic morphine treat-ment inhibits LPS-induced angiogenesis:implications in woundhealing[J].Cell Immunol,2010,265(2):139-145.
  • 3Shan F,Xia Y,Wang N,et al.Functional modulation of the path-way between dendritic cells(DCs)and CD4+T cells by the neu-ropeptide:methionine enkephalin(MENK)[J].Peptides,2011,32(5):929-937.
  • 4Chereshnev VA,Geǐn SV.Beta-endorphin as the endogenous regu-lator of immune processes[J].Ross Fiziol Zh Im I M Sechenova,2009,95(12):1279-1290.
  • 5Campana G,Sarti D,Spampinato S,et al.Long-term intrathecalmorphine and bupivacaine upregulate MOR gene expression inlymphocytes[J].Int Immunopharmacol,2010,10(9):1149-1152.
  • 6Liu H,Li H,Guo L,et al.The mechanism involved in the repres-sion of the mu opioid receptor gene expression in CEMx174 cellsinfected by simian immunodeficiency virus[J].J Leukoc Biol,2009,85(4):684-691.
  • 7Turchan-Cholewo J,Dimayuga FO,Gupta S,et al.Morphine andHIV-Tat increase microglial-free radical production and oxidativestress:possible role in cytokine regulation[J].J Neurochem,2009,108(1):202-215.
  • 8Turchan-Cholewo J,Fo DG,Gupta S,et al.Nociceptin-inducedmodulation of human T cell function[J].Peptides,2009,30(5):926-934.
  • 9Vojdani Z,Dehghani F,Seyedi F,et al.Quantitative study of theeffects of morphine on the mouse spleen and inguinal lymph node[J].Arch Iran Med,2010,13(4):294-300.
  • 10Liu H,Li H,Guo L,et al.Mechanisms involved in phosphatidyli-nositol 3-kinase pathway mediated up-regulation of the mu opioidreceptor in lymphocytes[J].Biochem Pharmacol,2010,79(3):516-523.

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医学综述
2015年 第4期

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