阻塞性睡眠呼吸暂停低通气综合征与脂肪因子Apelin-36的相关研究

Level of Adipokine Apelin-36 in Obstructive Sleep Apnea-hypopnea Syndrome

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血中脂肪因子Apelin-36的水平。方法选择2010年6月至2013年6月来都江堰市人民医院睡眠监测中心就诊的成年疑似OSAHS患者150例为研究对象,经多导睡眠监测将符合OSAHS者归纳为OSAHS组74例,不符合OSAHS者归为非OSAHS组76例,比较两组患者血清Apelin-36的水平。结果 OSAHS组患者血清中Apelin-36的水平较非OSAHS组显著增高[(445±55)ng/L比(378±52)ng/L],差异有统计学意义(t=2.364,P<0.05)。结论 OSAHS可导致血清中Apelin-36水平升高,可能是由于缺氧所致。

Objective To study the Apelin-36 level in obstructive sleep apnea hypopnea syndrome（ OSAHS） patients. Methods A total of 150 suspected OSAHS patients from Dujiangyan People＇s Hospital from Jun. 2010 to Jun. 2013 were included as study objects. According to polysomnogram,the patients were divided into OSAHS group（ 74 cases） and non-OSAHS group（ 76 cases）. The Apelin-36 level of the two groups was compared. Results The level of Apelin-36 in OSAHS group[（ 445 ± 55） ng / L] was significantly higher than non-OSAHS group [（ 378 ± 52） ng / L ]（ t = 2. 364,P〈0. 05）. Conclusion OSAHS can increase Apelin-36 level,probably due to hypoxia.