大柴胡汤治疗急性期脑梗死临床观察

Clinical Observation of Dachaihu Decoction in Treatment of Acute Cerebral Infarction

目的观察大柴胡汤治疗脑梗死急性期痰火上扰证的临床疗效,并探讨其作用机制。方法 49例脑梗死急性期患者随机分为两组,对照组给予基础治疗,治疗组在对照组基础上加用大柴胡汤颗粒。观察临床神经功能缺损恢复情况及相关生化指标的变化。结果治疗14d后,治疗组疗效优于对照组(P<0.05)。治疗前后两组美国国立卫生研究院脑卒中量表(NIHSS)、日常生活活动能力量表Barthel指数(BI)和实际完成日常生活活动的改良Rankin量表(MRS)评分均有差异,治疗组BI评分优于对照组(P<0.05)。治疗组及对照组同型半胱氨酸(Hcy)、C反应蛋白(CRP)均降低,治疗前后有显著差异性,C反应蛋白下降治疗组明显优于对照组(P<0.05)。结论大柴胡汤明显改善脑梗死急性期风痰瘀阻型患者各项神经功能缺损症状,改善患者的炎性反应,这也可能是其治疗急性脑梗死的重要作用机制。

Objective To observe the clinical effects of Dachaihu decoction in curing acute cerebral infarction and to explore the mechanism. Methods 49 cases of acute cerebral infarction were randomly divided into two groups,the control group was given basic treatment and the treatment group was given Dachaihu decoction based on the foundation treatmen. To observe the clinical nerve function defect recovery and related biochemical indicators of change. Results After 14 days＇ treatment,the curative effect of treatment group was better than that of control group（ P 0. 05）. The scores of two groups before and after the treatment at the national institutes of health stroke scale（ NIHSS）,daily life activities ability scale Barthel index（ BI） and the actual finish daily life activity of the modified Rankin scale（ MRS） score had difference,the treatment group BI score was better than the control group（ P 0. 05）. The treatment group and control group in homocysteine（ Hcy）,c- reactive protein（ CRP） were lower,there had significant difference before and after the treatment,c- reactive protein decreased in treatment group was better than control group（ P 0. 05）. Conclusion Dachaihui decoction can significantly improve acute cerebral infarction patients symptoms of meurological impairment; improve inflammatory reaction and it could also be the important mechanism for the treatment of acute cerebral infarction.