武汉地区妇女宫颈人乳头状瘤病毒感染的基因型分析

Genotypic Analysis of Wuhan Cervical Human Papilloma Virus Infection in Women

目的分析武汉地区妇女子宫颈人乳头状瘤病毒(HPV)感染状况及其基因亚型的分布特征。方法以1211例妇女作为研究对象,采集其宫颈脱落细胞,采用导流杂交法(Hybri Max)进行HPV基因分型检测。结果 HPV阳性数255例,感染率为21.06%。人群中感染最多的亚型依次为HPV-52、16、58亚型,感染率构成比分别为15.69%、14.9%、10.98%。各年龄段中,18-20岁检出率最高(P<0.001)。结论武汉地区妇科就诊患者的HPV感染率较高,并且以高危型HPV感染为主,其中最常见的亚型是HPV-52。

Objective To analyse the infection rate of HPV and the distribution characteristics of HPV genotype in women at gynecologic outpatient department in Wuhan. Methods 1211 patients were investigated cervical exfoliated cells and checked for 21 HPV DNA types by flow- through hybridization. Results 255 cases were detected HPV positive,accounting for 21. 06%. The infection rates of genotypes from high to low were HPV 52（ 15. 69%） 、HPV 16（ 14. 9%） and HPV 58（ 10. 98%）. The detection rate of HPV was higher in the patients aged between age 18 to 20 years（ P 0. 001）. Conclusion The infection rate of HPV at gynecologic outpatient department in Wuhan is high. The high- risk HPV genotypes were the major genotypes causing infection. The most common genogype is HPV 52.