间充质干细胞移植治疗帕金森病的作用机制研究进展

Research progress on function mechanism of Mesenchymal stem cells transplantation for Parkinson's disease

帕金森病(Parkinson's Disease,PD)的主要病理改变是黑质多巴胺能神经元进行性变性致纹状体多巴胺递质浓度显著降低,从而出现运动障碍。目前,药物和外科手术治疗可一定程度改善早期PD的部分临床症状,但并不能阻止或逆转多巴胺能神经元变性。近些年,间充质干细胞(Mesenchymal Stem Cells,MSCs)移植作为治疗PD的最前沿方法,其疗效备受瞩目。本文就MSCs移植促进PD神经功能恢复的可能作用机制作一综述。

The main pathological changes of Parkinson＇s disease（ PD） are the progressive degeneration of dopaminergic neurons in the area of substantia nigra,which results in dopamine reduced sharply in the striatum,and develops movement disorders. At present,to a certain extent,drug and surgical treatment can partially improve the clinical symptoms of early PD,but cannot prevent or reverse dopaminergic neuron degeneration. In recent years,Mesenchymal stem cells（ MSCs） transplantation,as a forefront of treatment method for PD,attracts tremendous attention because of its curative effect. This article reviewed the possible function mechanisms of MSCs transplantation promote the neural functional recovery of PD.