摘要
糖尿病是严重危害人类健康的重大疾病之一。现有的药物存在耐药性、胃肠道反应等问题,亟待开发新型的抗糖尿病药物。本文综述了近年来具有抗糖尿病活性的含糖结构的螺环化合物研究进展,重点介绍了部分螺环化合物的合成方法、生理活性及其构效关系。
Diabetes mellitus （DM） is one of the severe diseases harmful to human health. It＇s urgent to develop new anti-diabetic drugs due to drug resistance, gastrointestinal disturbances and other problems. The progress of the research on sugar-containing spiro-compounds with anti-diabetic activities in recent years is reviewed in this article, in which the synthetic methods, biological activities, and structure-activity relationships of these com pounds are summarized.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2015年第4期421-426,共6页
Chinese Journal of New Drugs
基金
国家自然科学基金(21472069)
中央高校基本科研业务费资助项目(JUSRP1040)
关键词
含糖结构
螺环化合物
抗糖尿病活性
合成
构效关系
sugar-containing structure
spiro-compounds
anti-diabetic activities
synthesis
structure-ac-tivity relationships （SARs）
