儿童过敏性紫癜肾脏损伤早期诊断的判别统计分析

Using discriminate analysis to predict the early renal injury of children with Henoch-Schonlein Purpura

目的:准确判断儿童过敏性紫癜(HSP)有无肾脏早期损伤.方法:检测46例HSP患儿和28例正常儿童的血小板计数(PLT)、平均血小板体积(MPV)及血小板分布宽度(PDW)和尿系列蛋白ALB、Ig G及β2-微球蛋白的水平,应用判别统计分析方法,并且拟合出非标准化判别方程,研究HSP普通型和HSP肾型病人的分类,以及上述六项指标分别对HSP肾脏早期损伤作用的大小.结果:HSP普通型病人组判别正确率为80.0%,HSP肾型病人组为81.0%,正常人组为100%,总判别正确率为87.8%;另外PDW和MPV对HSP肾脏早期损伤病人的筛选有较大的作用.结论:应用判别统计分析方法分析血小板参数及尿系列蛋白的指数有助于发现HSP患儿早期肾损害.

Aim：Predicting whether children with Henoch-Schonlein purpura（HSP）have the early re-nal damage.Methods：46 patients and 28 healthy children were measured the level of platelet parameter （PLT,MPV,PDW）and urine protein series （ALB,IgG and β2-MG）.Results：For HSP ordinary type patients,the correct ratio of discrimination was 80.0%;for HSP Kidney damage group,the correct ratio of discrimination was 81.0%;and the correct ratio of discrimination of normal children was 100%;87.8% of original grouped cases correctly classified.In addition,PDW and MPV had greater effect on screening for early renal damage in patients with HSP.Conclusion：Using discriminate analysis to analyze the platelet parameters and urine protein series can reveal early renal damage in HSP patients and might be used as an indicator for early diagnosis.