脑缺血预适应标志物的评估

Biomarkers for Cerebral Ischemic Preconditioning

缺血预适应是一种内源性神经保护机制,即短暂的、非致死缺血损伤保护后续的致死性缺血打击。它通过短暂的缺血诱导固有的防御系统,引起对随后的严重缺血的耐受。预适应存在于多种器官及生物,其中脑缺血预适应受到了广泛的关注。找到适合的标志物以表明预适应反应诱发的缺血耐受是转化研究的重点。理想的标志物应易于获得,有较高的敏感性及特异性。本文将对可能反映缺血预适应诱发的缺血耐受状态的血清及影像学标志物予以综述。

Ischemic preconditioning（IPC） is an intrinsic neuroprotective mechanism whereby a brief,sublethal ischemic insult protects against a subsequent lethal ischemic attack.Its basic premise is that brief durations of ischemia induce innate defense systems leading to tolerance of subsequent,more severe ischemia.Preconditioning has been observed in multiple organs and species,among which cerebral ischemic preconditioning had gained much more attention.Finding suitable biomarkers to show the ischemic tolerance induced by ischemic preconditioning is a translational research priority.The ideal biomarker should be easily obtained,with high sensitivity and specificity.In this article,we will review the probable serum and imaging biomarkers for cerebral ischemic tolerance induced by ischemic preconditioning.