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脑出血后血脑屏障损害研究进展 被引量：4

Research Review on the Damage of Blood-Brain Barrier after Cerebral Hemorrhage
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摘要 脑水肿是脑出血的严重并发症之一,其中血脑屏障损害导致的血管源性脑水肿是脑出血后脑水肿的主要类型。凝血酶、炎症因子、基质金属蛋白酶、补体、血红蛋白降解产物、水通道蛋白4等以及这些因子间的相互作用都可能在脑出血后血脑屏障损害病理过程中发挥重要作用,本文对此做一综述。 Brain edema is one of the serious complications caused by hemorrhagic stroke,in which the vasogenic brain edema caused by blood-brain barrier damage is the main type of cerebral edema.At present,a number of studies have shown that there are various factors inducing bloodbrain barrier disruption after cerebral hemorrhage.For instance,thrombin,inflammatory mediators,matrix metalloproteinases,complement,hemoglobin breakdown products,aquaporin-4 and the interactions of them all play a significant role in this pathophysiological process.
作者 许楠 曹非
机构地区 华中科技大学同济医学院附属协和医院神经内科
出处 《中国卒中杂志》 2015年第2期181-186,共6页 Chinese Journal of Stroke
基金 武汉市科技攻关项目(2013060602010234) 天普凯力康研究基金项目(KF201204) 养血清脑颗粒治疗急性缺血性脑卒中实验研究项目
关键词 脑出血 脑水肿 血脑屏障损害 Cerebral hemorrhage Brain edema Blood-brain barrier damage
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献41

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二级参考文献27

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共引文献12

同被引文献27

  • 1全国第四届脑血管病学术会议.脑卒中患者临床神经功能损伤程度评分标准及临床疗效评定标准.中华神经科杂志,1996,.
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引证文献4

二级引证文献45

中国卒中杂志
2015年 第2期

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