高敏肌钙蛋白在非ST段抬高急性冠状动脉综合征诊断中的临床应用

Clinical Significance of High-sensitivity Cardiac Troponin in Non-ST-segment Elevation Acute Coronary Syndrome

目的探讨高敏肌钙蛋白在非ST段抬高急性冠状动脉综合征诊断中的临床应用价值。方法选取2012年10月—2013年12月期间在我院住院的非ST段抬高急性冠状动脉综合征(NSTE-ACS)患者127例,其中非ST段抬高型心肌梗死患者62例,不稳定型心绞痛患者65例,入院时采集患者外周静脉血测定高敏感性肌钙蛋白hs-cTn、hs-cTnI。结果非ST段抬高型心肌梗死组患者的hs-cTnT、hs-cTnI水平均比不稳定型心绞痛组高(P<0.05)。hscTnT>106pg/ml、hs-cTnI>62pg/ml是诊断非ST段抬高型心肌梗死的最佳诊断界值,且诊断灵敏性、特异性相似。结论高敏肌钙蛋白对NSTE-ACS具有重要的诊断价值,早期筛检有利于对NSTE-ACS患者进行临床对症治疗。

Objective To test clinical significance of high-sensitivity cardiac troponin in non-ST-segment elevation acute coronary syndrome.Methods One hundred and twenty-seven patients of non-ST-segment elevation acute coronary syndrome from Oct 2012 to Dec 2013.In which the non ST segment elevation acute myocardial infarction were 62 cases,unstable angina pectoris were 65 cases.The serum samples were test for hs-cTnT and hs-cTnI simueltaneously.Results Both the serum hs-cTnT and hs-cTnI levels in non-ST-segment elevation acute myocardial infarction group were higher than the unstable angina pectoris group（P〈0.05）,hs-cTnT〉106pg/ml、hs-cTnI〉62pg/ml were the best prognostic accuracy,with equal specificity and sensitivity for both assays.Conclusion High-sensitivity cardiac troponin provides significant prognostic value for NSTE-ACS,and early screening has positive clinical significance for the curation of NSTE-ACS patients.