IL-10-592A/C基因多态性与结核病易感性关系的Meta分析

Association of IL-10-592A/C Gene Polymorphism with Tuberculosis Risk:A Meta-analysis

目的:探讨白细胞介素-10(IL-10)基因592A/C位点多态性与结核病易感性的关系。方法:检索PubMed、Medline、EMbase等数据库,搜集相关病例对照研究文献。文献经筛选和方法学质量评价后,采用Stata12.0软件进行Meta分析,计算合并OR值及其95%CI,最后进行敏感性分析及发表偏倚评估。结果:共16篇文献纳入研究,包括结核病患者(病例组)4 115例,健康体检者(对照组)5 441例。Meta分析显示,在各个遗传模型中,IL-10-592A/C基因多态性与结核病总体发病风险关系不大。对纳入研究以世界各洲为分层因素进行分析,在亚洲人群中等位基因A者结核病发病率高于等位基因C者(OR=1.26,95%CI=1.08-1.28,P<0.05);纯合子基因型AA者结核病发病率高于纯合子基因型CC者(OR=1.50,95%CI=1.07-2.12,P<0.05);纯合子基因型AA者结核病发病率高于AC+CC基因型者(OR=1.33,95%CI=1.10-1.62,P<0.05)。经Begg’s与Egger’s检验,纳入的所有研究未见明显发表偏倚。结论:IL-10-592A/C基因多态性中等位基因A可能与亚洲人群结核病易感性风险增高有关。

Objective：To investigate the association between interleukin-10（IL-10）gene promoter-592A/C polymorphism and tuberculosis（TB）susceptibility.Method：Such databases as PubMed,MEDLINE and EMbase data were searched to collect the case-control studies published.According to the inclusion and exclusion criteria,the studies were screened,the data were extracted,and the methodological quality of the included studies was evaluated.Then meta-analysis was conducted using Stata 12.0sotware,the pooled odds ratio（ORs）with 95%conidence interval（CI）were calculated,and the sensitivity and publication bias were evaluated at the same time.Results：A total of 16 studies were included,which involved 4115 cases and 5441 healthy controls.The results of meta-analysis showed that,the IL-10-592A/C polymorphism had no association with a increased risk of TB.In the stratified analysis by ethnicity,significantly increased risk of TB was associated with Asians in IL-10-592A/C polymorphism（A vs.C：OR=1.26,95% CI=1.08-1.28,P〈0.05;AA vs.CC：OR=1.50,95% CI=1.07-2.12,P〈0.05;AA vs.AC＋CC：OR=1.33,95% CI=1.10-1.62,P〈0.05）.All of the included studies showed no publication bias by Begg’s and Egger’s test.Conclusion：IL-10-592A/C polymorphism in allele A might be a genetic risk factor that increases TB susceptibility for Asians.