Indole-tolerant Oxidation of 1,2-Diarylalkynes to 1,2-Diketone Derivatives
Indole-tolerant Oxidation of 1,2-Diarylalkynes to 1,2-Diketone Derivatives
摘要
A new indole-tolerant oxidation condition for the synthesis of 1,2-diketone derivatives from the corresponding 1,2-diarylalkynes was described. By screening a series of oxidation systems on alkynes linked with indole and different substituted aromatic ring, the DMSO/PdCl2/CuCl2 system afforded moderate to good yields despite the existence of electron-rich indole ring.
A new indole-tolerant oxidation condition for the synthesis of 1,2-diketone derivatives from the corresponding 1,2-diarylalkynes was described. By screening a series of oxidation systems on alkynes linked with indole and different substituted aromatic ring, the DMSO/PdCl2/CuCl2 system afforded moderate to good yields despite the existence of electron-rich indole ring.
基金
Supported by the National Natural Science Foundation of China（Nos.81373259, 81102324）.
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