通窍活血汤联合窄谱中波紫外线治疗口腔扁平苔癣的临床疗效

Clinical effect of Tongqiao Huoxue Decoction combined with narrow band UVB for treating lichen planus

目的探讨通窍活血汤联合窄谱中波紫外线治疗扁平苔癣的效果。方法口腔扁平苔癣患者64例按就诊顺序单双号分为治疗组与对照组各32例,两组都给予窄谱中波紫外线治疗,治疗组在对照组治疗的基础上给予通窍活血汤治疗,均治疗15 d。观察两组的治疗总有效率、不良反应与复发情况,同时对治疗前后的血浆黏度进行检测。结果治疗组的总有效率为100.0%,对照组总有效率为87.5%,治疗组的总有效率明显高于对照组(P<0.05)。两组治疗期间皮肤过敏、胃肠症状、尿潴留、精神症状等不良反应发生情况对比差异无统计学意义,对症处理后均明显好转。治疗后两组的血浆黏度都呈现明显下降趋势(P<0.05),同时治疗后治疗组的血浆黏度明显低于对照组(P<0.05);两组不同时间点的红细胞压积对比差异无统计学意义。治疗后6个月进行电话随访,治疗组的复发率为0,对照组复发率为12.5%,治疗组的复发率明显低于对照组(P<0.05)。结论通窍活血汤联合窄谱中波紫外线治疗扁平苔癣能有效降低血浆黏度,从而提高治疗疗效,减少复发,安全性也比较好,值得推广应用。

Objective To investigate the effects of Tongqiao Huoxue Decoction（THD） combined with narrow band UVB for treating lichen planus. Methods Lichen planus patients（64 cases） were equally divided into treatment and the control groups based on the odd and even order numbers. The patients in both groups were given narrow band UVB therapy, the patients in treatment group received THD for treatment, and all patients were treated for 15 d. The total efficiency, adverse reactions, and relapse were observed, while the plasma viscosity before and after treatment was detected. Results The total efficiency in the treatment group was 100.0%, and that in the control group was 87.5%. The total efficiency in the treatment group was significantly higher（P〈0.05）. During the treatment, the adverse reactions of skin allergies, gastrointestinal symptoms, urinary retention, and psychiatric symptoms in the two groups had no statistically significant differences and all were significantly improved after symptomatic treatment. After treatment, the plasma viscosity showed clear downward trend（P〈0.05）, while the plasma viscosity after treatment in the treatment group were significantly lower than that in the control group（P〈0.05）; The hematocrit values in two groups at different time were not significantly different. Through telephone followed-up after 6 months of treatment, the recurrence rate in the treatment group was 0.0%, and that in the control group was 12.5%. The recurrence rate in the treatment group was significantly lower than that in the control group（P〈0.05）. Conclusion THD combined with narrow band UVB for treating lichen planus can effectively reduce plasma viscosity, thereby enhance the therapeutic efficacy and reduce recurrence, and its security is relatively good that should be widely applied.