增液八珍汤治疗习惯性便秘

Zengye Bazhen Decoction in treating habit constipation

目的观察增液八珍汤治疗习惯性便秘的临床疗效。方法将100例习惯性便秘的患者随机分成治疗组和对照组,各50例。治疗组口服增液八珍汤(党参、白术、茯苓、当归等,1剂/d,早晚分服)治疗;对照组口服西沙比利(10 mg/次,3次/d,饭前口服),疗程1个月。分别检测治疗前后受试者血清中胃泌素(GAS)、P物质(SP)、生长抑素(SS)的含量。结果治疗组治愈率58%,总有效率为98%,复发率10.3%;对照组治愈率24%,总有效率为72%,复发率33.3%。2组治愈率、总有效率比较,差异有统计学意义(P<0.01,P<0.05);治疗前后2组受试者血清中胃泌素(GAS)、P物质(SP)、生长抑素(SS)含量均有明显变化,治疗组变化明显优于对照组(P<0.05)。结论增液八珍汤治疗习惯性便秘复发率低,无毒副作用,并能改善血清中GAS、SP、SS含量。

Objective In order to observe the clinical effect of Zengye Bazhen Decoction in treating habit constipation.Methods The 100 cases with habitual constipation were randomly divided into two groups,50 cases in each group. The treatment group took Zengye Bazhen Decoction（ dangshen,atractylodes,poria cocos,angelica,1 dose / d,in the morning and evening） by oral; while the control group took cisapride（ 10 mg / time,3 times / d,before meal） by oral,for a-monthtreatment. Test the GAS,SP,SS level in the blood before and after treatment. Results The cure rate of treatment group was 58%,efficiency was 98%,recurrence rate was 10. 3%; the cure rate of the control group was 24%,efficiency was72%,recurrence rate was 33. 3%. There was significant difference（ P〈0. 01,P〈0. 05） between the treatment group and the control group before and after treatment; Study suggested the content of GAS,SP,SS had obvious changed,the treatment group was better than the control group（ P〈0. 05）. Conclusion Zengye Bazhen Decoction had curative effect,low recurrence rate and no toxic side effect in the treatment of habitual constipation.