软肝利胆汤对肝癌术后无病生存期的影响

Ruanganlidan decoction on disease-free survival after a radical liver resection

目的 从临床角度寻找延长肝癌术后无病生存期的有效治疗方法。方法 病例选择78例均有乙肝病史,接受过肝癌根治性切除术,术后均行2~3次TACE治疗的肝癌患者,将可能影响原发性肝癌术后无病生存期的观察指标包括性别、年龄、酗酒史、乙肝病毒控制情况、Child-Pugh分级、门静脉癌栓、术前甲胎蛋白值、肿瘤直径、血管是否侵犯、切缘距离、中医中药治疗等,用Cox模型分析各因素与无病生存期之间的关系。结果 年纪稍大、乙肝病毒控制良好、Child-Pugh A级、无门静脉癌栓、原发肿瘤越小、无血管侵犯、术后行中药软肝利胆汤治疗,且服中药时间长均可延长肝癌术后无病生存期。结论 肝癌术后坚持服用中药软肝利胆汤有助于预防复发转移,对延长肝癌术后患者无病生存期具有一定作用。

Objective To find a clinical method to prolong disease-free survival（ DFS） after a radical liver resection in patients with Hepatocellular Carcinoma. Methods A total of 78 patients with hepatocellular carcinoma had a Hepatitis B virus（ HBV） infection,received radical liver resection and TACE treatment 2-3 times after surgery. Variables might related with DFS including sex,age,history of excessive drinking,HBV infection controls,Child-Pugh grading,portal vein thrombosis,preoperative AFP level,tumor size,vascular invasion,resection margin,treatment of Ruanganlidan decoction were used in the multivariate analysis using the Cox proportional hazard model to analyze factors affecting on DFS. Results On multivariate analysis by Cox proportional hazard model,older HCC patients,good control of HBV infection,Child-Pugh A grade,no exist of portal vein thrombosis,smaller tumor diameter,no vascular invasion,receive treatment of Ruanganlidan Tang had a longer DFS Significantly. The longer the patients received treatment of Ruanganlidan decoction,the longer they had a DFS. Conclusion Receiving treatment of Ruanganlidan decoction after a radical liver resection in patients with Hepatocellular Carcinoma is benefit to prolong DFS.