银杏内酯对缺血性脑血管疾病的药理研究进展

Progress on Pharmacology of Ginkgolides for Ischemic Cerebrovascular Diseases

银杏内酯是银杏叶中的重要药用成分。大量关于银杏内酯的实验研究与临床试验证明,银杏内酯对缺血性脑血管疾病具有一定的治疗和预防作用。笔者将近十几年来有关银杏内酯的实验研究文献整理分析进行综述。在多种脑缺血模型中,银杏内酯显示了强效的脑保护作用,可明显改善神经症状,减轻脑水肿,缩小梗死面积;其通过多种途径发挥抗脑缺血损伤的作用,如抑制炎症反应,清除自由基、防止脂质过氧化,改善能量代谢和抑制兴奋性氨基酸等。

Ginkgolides is one of the important medicinal ingredients in ginkgo.An abundance of studies verify that ginkgolides does work in both treatment and prevention of cerebrovascular diseases.This review analyzed decades documents about experimental researches of ginkgolides.Various cerebral-ischemia models show that ginkgolides has great cerebral protective effects.It can significantly improve neurological symptoms,relieve cerebral edema and reduce the volume of cerebral infarction.It plays an important role in preventing injury of cerebral ischemia by different ways,such as inhibiting inflammation,anti-oxidation protection,improving energy metabolism and resisting the release of excitatory amino acid.