肾嗜酸细胞腺瘤临床病理分析并文献复习

Clinicopathologic Analysis and literature Review of Renal Oncocytoma

目的探讨肾嗜酸细胞腺瘤的临床病理学特点及诊断要点。方法对我院收治的肾嗜酸细胞腺瘤3例的临床资料、病理形态学及免疫组化结果进行分析,并结合文献对其诊断及鉴别诊断进行探讨。结果本组中肾占位2例,肾上腺占位1例。镜下可见肿瘤细胞排列呈实性巢索状、乳头状或呈腺泡结构,胞质丰富,嗜酸,间质少,伴透明样变性;瘤细胞呈圆形或多角形,细胞核圆形规则,染色质分布均匀,核仁位于中央,核分裂象少见。免疫组化显示CK、EMA表达均阳性,Vimentin、Hale胶体铁表达均阴性。病理诊断肾嗜酸细胞腺瘤。结论肾嗜酸细胞腺瘤较少见,提高对该病的认识,对避免误诊至关重要。

Objective To explore the clinicopathologic characteristics and diagnostic criteria of renal oncocytoma. Methods The clinical data,pathomorphology and immunohistochemical staining results of 3 patients with renal oncocytoma were analyzed,and its diagnosis and differential diagnosis were studied in combination of with the literature.Results Two patients were found to have kidney lesion,and one patient was found to have adrenal mass. Microscopic examination showed that the tumor cells were arranged in the form of solid nest,papillary or acinar structures,and with abundant eosinophilic cytoplasm and less hyaline degeneration in interstitial tissue; the tumor cells were round or polygonal,and the cell nucleus was round and regular,chromatin was well distributed,the nucleolus was located centrally,and there were rare mitotic figures. Immunohistochemical staining showed that the expressions of CK and EMA were positive,and the expressions of Vimentin and Hale colloidal iron staining were negative. Pathologic diagnosis was renal oncocytoma. Conclusion Renal oncocytoma is rare,and it is essential to avoid misdiagnosis by raising awareness of the disease.