利巴韦林联合喜炎平治疗小儿手足口病60例疗效观察

Effect Observation of Ribavirin Combined with Xiyanping in the Treatment of 60 Cases of Children with Hand Foot and Mouth Disease

目的探讨小儿手足口病患儿应用利巴韦林和喜炎平联合治疗的临床疗效及其安全性。方法将我院收治的60例小儿手足口病患儿随机分为观察组和对照组各30例,观察组采用利巴韦林联合喜炎平治疗,对照组仅给予利巴韦林治疗。观察对比两组患儿的临床疗效、患儿皮疹消失时间、体温恢复正常时间、痊愈时间以及不良反应情况。结果观察组患儿治疗总有效率为96.7%,明显高于对照组的73.3%,差异具有统计学意义(P<0.05);观察组患儿皮疹消失时间、体温恢复正常时间以及痊愈时间明显短于对照组,差异均具有显著的统计学意义(P<0.05);两组患儿均未出现严重不良反应,差异无统计学意义(P>0.05)。结论小儿手足口病患儿应用利巴韦林和喜炎平联合治疗的临床疗效显著,可有效缓解患儿临床症状,缩短患儿痊愈时间,且不良反应较轻,值得在临床上进一步推广。

Objective To investigate the clinical efficacy and safety of ribavirin combined with Xiyanping in the treatment of children with hand foot and mouth disease（HFMD）. Methods 60 cases of HFMD children admitted to our hospital were randomly divided into observation group and control group, with 30 cases in each group. The observation group was treated with ribavirin combined with Xiyanping, the control group was only given ribavirin for treating. The clinical effect, rash disappeared time, temperature recovery time,healing time and adverse reactions of the two groups were observed and compared. Results The total effective rate of the observation group was 96.7%, significantly higher than 73.3% of the control group, with statistical difference（P 0.05）; the rash disappeared time, temperature recovery time and healing time of the observation group were significantly shorter than those of the control group（P 0.05）; serious adverse reactions were not found in the two groups, without statistical difference（P 0.05）. Conclusions Ribavirin combined with Xiyanping has significant clinical effect in treating pediatric hand foot mouth disease, and can effectively relieve children＇s clinical symptoms and shorten the healing time with mild adverse reactions, which deserves further promotion in clinic.