银屑病患者血脂水平分析

Analysis on concentrations of serum lipids in patients with psoriasis

目的研究银屑病患者脂代谢紊乱情况,分析不同类型银屑病患者血脂变化特点。方法将332例银屑病患者按临床表现分为脓疱型、寻常型及红皮病型,比较各组间的血脂水平。结果与对照组比较,银屑病组总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)水平较低,差异有统计学意义(P<0.05),脂蛋白[Lp(a)]水平较高,差异有统计学意义(P<0.05);脓疱型银屑病型与寻常型、红皮病型相比,血清TC、HDL-C、LDL-C及ApoA1均较低,差异有统计学意义(P<0.05)。结论银屑病患者体内存在脂代谢紊乱,且其紊乱严重情况可能与疾病类型有关。

Objective To investigate the dyslipidemia in patients with psoriasis,and the characteristics of the serum lipids in patients with different types of psoriasis.Methods 332 psoriatic patients were devided into pustular psoriatic,psoriasis vulgaris and erythrodermic psoriasis based on clinical manifestations.Serum lipids of the three groups were analyzed including TC,TG,HDL-C,LDL-C,ApoA1,ApoB and Lp（a）.Results The serum concentrations of TC,HDL-C,ApoA1 in patients with psoriasis were significantly lower than those in control group（P〈0.05）,while the concentration of Lp（a）was significantly higher in psoriasis patients compared with those in control group（P〈0.05）.The serum level of TC,HDL-C,LDL-C and ApoA1 in pustular psoriasis group were significantly lower than those in the other two groups（P〈0.05）.Conclusion The patients with psoriasis have dyslipidemia,and the serious disorder situation could be associated with psoriasis types.