小儿先天性心脏病介入术后阿司匹林服药依从性的管理

Anti-clotting Drug Surveillance and Follow-up on Medication Compliance and Therapeutic Effect of Children with Congenital Heart Disease

目的探讨抗凝药物服药监测和随访机制对于先天性心脏病患儿服药依从性的影响。方法采用前瞻、随机、对照方法,将120例先天性心脏病患儿及家属分为对照组和干预组。对照组予常规药物健康宣教,干预组在此基础上采用服药监测和随访机制。术后半年,比较两组阿司匹林认知程度及服药依从性的差异。结果干预组阿司匹林认知程度和服药依从性明显高于对照组,药物不良反应发生率明显低于对照组(P<0.05)。结论设计并应用药物服用监测记录表,完善并增加电话随访和复诊,可提高先天性心脏病介入术后阿司匹林服药依从性,减少不良反应。

Objective To study the effect of anti-clotting drug surveillance and follow-up on medication compliance and therapeutic effect of children with congenital heart disease （CHD）. Methods By prospective randomized controlled trials, 120 children with CHD and their family members were divided into control group with conventional medication health education and intervention group with medication surveillance and follow-up. After half a year, the differences of cognition degree and medication compliance for aspirin were compared. Results The level of cognition degree and medication compliance in intervention group were higher than those in control group （P〈0.05）and the incidence of adverse drug reaction in intervention group was significant lower that in control group. Conclusion Positive scientific medication surveillance and follow-up can improve the medication compliance and postoperative medication safety and avoid the occurrence of thrombosis.