摘要
目的探讨沙格列汀对2型糖尿病患者的疗效及其对血液流变学、血管弹性的影响。方法 60例2型糖尿病患者随机分为2组,每组30例。对照组二甲双胍0.5 g,bid,逐渐加至每日2 g,分次服用。观察组在对照组基础上加服沙格列汀5 mg,qd。2组疗程均为12周。观察比较2组患者的血脂、空腹血糖、餐后2 h血糖、糖化血红蛋白、体质指数、血液流变学及血管弹性的变化情况。结果治疗前后2组血脂指标的差异无统计学意义(P>0.05)。治疗后,观察组的血糖及体质指数方面差异均有统计学意义(P<0.05)。治疗前后2组患者的血液流变学与血管弹性方面差异均无统计学意义(P>0.05)。结论沙格列汀治疗2型糖尿病能够有效改善患者血糖,但对改善患者血液流变学及血管弹性无明显作用。
Objective To evaluate the effect of saxagliptin intervention on blood rheology and blood vessel elasticity on patients with type 2diabetes. Methods Sixty cases of type 2 diabetes patients were randomly divided into two groups,30 patients in each group. Patients in control group were given metformin 0. 5 g,bid,and then the dose went up to 2 g gradually( divided into many times). Patients in observation group were given metformin combined with saxagliptin 5 mg,qd. The treatment lasted for 12 weeks. The data of lipids,fasting plasma glucose,postprandial 2 h glucose,glycosylated hemoglobin,body mass index,blood rheology and blood vessel elasticity in two groups were compared. Results Compared with before treatment,there was no significant difference found in lipid index of two group after treatment( P〉0. 05),while the glucose and body mass index in observation group were significantly different( P〈0. 05).After treatment,there was no significant difference found in data of blood rheology and blood vessel elasticity in two groups( P〉0. 05). Conclusion Saxagliptin for the treatment of type 2 diabetes can improve blood glucose of patients,but no significant impact on the hemorheology and blood vessel elasticity is found.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第3期169-171,192,共4页
The Chinese Journal of Clinical Pharmacology
关键词
沙格列汀
2型糖尿病
血液流变学
血管弹性
二甲双胍
血脂
saxagliptin
type 2 diabetes
hemorheology
blood vessel elasticity
metformin
blood lipid