红霉素长期小剂量超说明书用药的文献计量分析

Bibliometric analysis of the long-term low-dose off-label use of erythromycin

目的用文献计量学方法分析红霉素长期小剂量超说明书用药及其研究热点,为红霉素的超说明书用药研究提供参考。方法检索自建库到2014年10月Pub Med、Em Base、SCI及中国知网(CNKI)数据库公开发表的文献,用End Note软件进行整理,对其发表年份、文献类型、研究热点和内容进行计量分析。结果共纳入文献694篇,其中外文451篇,中文243篇;文献以论著(545篇)为主;被引频次最高为275次。外文和中文第1篇文献分别发表于1974,1990年。研究内容包括红霉素长期小剂量超说明书用药应用的临床表现、治疗现状和治疗效果及不良反应等。结论长期小剂量的红霉素治疗在慢性炎症性呼吸系统疾病有效,在儿科红霉素作为促胃肠动力药的研究是目前的研究热点。

Objective To analyze the correlation analysis as on long-term low- dose off- label use of erythromycin with bibliometric approach,and to provide reference for study on off- label use of erythromycin. Methods Literatures were searched in Pub Med,Em Base,Science Citation Index and CNKI data- bases from beginning to October2014. End Note was used to sort these articles and the bibliometric analysis was carried out in respect of published years,document type and research hotspot etc. Results The final document included a total of694,including 451 foreign languages,Chinese 243. Among 694 papers,there were 545 pieces of original articles; the most frequently cited paper was cited for 275 times. First foreign language study on the long- term low- dose erythromycin treatment was published in 1974. Chinese from1990 published his first articles. The research contents include clinical manifestations,present status of treatment,therapeutic effect and adverse drug reaction of long- term low- dose erythromycin application.Conclusion The current study found that long- term low- dose erythromycin on chronic inflammatory lung disease effectively,and erythromycin stomach action by promoting the use of pediatric clinical study is currently hot.