中和抗体和细胞免疫在病毒疫苗有效性评价中的相互关系

Relationship between neutralizing antibody and cellular immunity in effect evaluation of viral vaccines

在病毒疫苗有效性评价中,中和抗体和细胞免疫是相辅相成的两个方面。但是,因为疫苗种类不同,针对不同病毒,其诱导中和抗体和细胞免疫的机制也不同,因此,对疫苗有效性评价尚无统一的标准。然而,用科学的方法检测疫苗诱导的中和抗体和细胞免疫,针对不同的病毒疫苗建立科学有效的检测标准,对疫苗有效性评价及发展均有重要意义。本文就上述问题探讨中和抗体和细胞免疫在病毒疫苗有效性评价中的相互关系。

Neutralizing antibody and cellular immunity are two important aspects of the effect evaluation of viral vaccines. However,because of the differences in the vaccine category and the induction mechanisms of neutralizing antibody and cellular immunity to the viruses, uniform criterion has not been established to evaluate the effect of the viral vaccines. Thus,it is important to develop and assess the viral vaccines to establish effective standards and assays for the determination of neutralizing antibody and cellular immunity to various viruses.