脑脊液细胞学853例临床分析

Cerebrospinal fluid cytology and 853 cases clinical analysis

目的回顾本实验室853例脑脊液细胞学(CSFC)检查结果分析,探讨其临床应用价值。方法2008年4月至2012年4月CSFC 853例,脑脊液CFSC标本经自然沉淀法或玻片离心法制片,常规采用迈-格-姬染色、观察。结果总结分析853例检查结果,阳性结果 56例,占全部CSFC的6.57%。发现中枢神经系统感染性疾病39例(其中包括新型隐球菌感染2例),中枢神经系统白血病4例,中枢神经系统肿瘤7例(脑室髓母细胞瘤1例),蛛网膜下腔出血3例,静脉窦血栓3例。结论 CSFC对于中枢神经系统疾病的诊断和鉴别诊断具很高临床应用价值。发现中枢神经系统感染以结核、病毒、细菌多见,新型隐球菌、蛛网膜下腔出血、静脉窦血栓形成少见,本文所见的肿瘤细胞以转移癌多见。

Objective To review of the laboratory 853 cases of cerebrospinal fluid cytology （CSFC） results, to investigate its clinical value.Methods From April 2008 to April 2012 the CSFC in 853 cases, CSFsamples from natural precipitation or slide centrifugal process piece, conventional step-grid-Giemsa staining was observed. Results The retrospective study analyzed 853 cases of CSFC results, positive results in 56 cases, accounting for 6.57% of all CSFC. Found 39 cases of central nervous system infection （ including cryptococcus neoformans infection in 2 cases）, central nervous system leukemia cases, seven cases of central nervous system tumors （ventricle mednlloblastoma）, 3 cases of subarachnoid hemorrhage, venous sinus thrombosis in 3 cases.Conclusion CSFC for the diagnosis of central nervous system diseases and differential diagnosis with high clinical value. Found that the infection of the central nervous system tuberculosis, viruses, bacterial pathogens common, visible cryptococcus neoformans visible subarachnoid hemorrhage, venous sinus thrombosis misdiagnosed cases seen in the tumor cells to metastatic cancer is more common.