应用遥测技术对SHR大鼠血压、心率变异性月龄动态变化和性别差异的研究

Study on dynamic changes and gender difference of heart rate variability and blood pressure variability via implantable telemetry technology in spontaneously hypertensive rats

目的应用植入式遥测技术观察不同周龄和性别自发性高血压大鼠的清醒无束缚状态下血压和心率变异性的变化。方法取16只雌雄各半SPF级3月龄SHR大鼠,进行TL11M2-C50-PXT植入手术后恢复7 d开始实验,在SHR大鼠3、5、7月龄时分别进行24 h连续清醒无束缚的血压和心电监测,计算24 h的收缩压、平均压、舒张压、血压变异性和心率变异性各项指标。结果 SHR大鼠随着月龄增加而24 h收缩压、平均压、舒张压和血压变异性升高,雌性SHR大鼠血压变异性明显低于雄性。3、5、7月龄雄性SHR大鼠心率变异性相关指标之间比较无明显变化,但雌性SHR大鼠随着月龄增加而RR间期、SDNN、TP、VLF和HF明显升高,且雌性SHR大鼠TP、VLF和HF等心率变异性指标均低于雄性。结论随着SHR大鼠周龄增加而血压、血压变异性升高,且雌性SHR大鼠血压变异性和心率变异性明显低于雄性。

Objective To observation dynamic changes and gender difference of heart rate variability and blood pressure variability in unbonded spontaneously hypertensive rats using Telemetry technology. Method Taking sixteen spontaneously hypertensive rats of 3-month-old in SPF grade, there were implanted TL11M2-C50-PXT device intraperitoneally. Seven days later,respectively monitoring chainless blood pressure and electrocardiogram for 24 h continuously time using telemetry system when 3,5,7 months of age in spontaneously hypertensive rats. Analysing 24 h systolic pressure,mean blood pressure,diastolic blood pressure,heart rate variability and blood pressure variability.Result Systolic pressure,diastolic pressure and mean pressure,blood pressure variability increased with age of the moonincreased in spontaneously hypertensive rats,moreover female SHR rats of blood pressure variability was significantly lower than that of the male rats. Correlated indexes of heart rate variability had no obvious change Between three to seven monthold in male spontaneously hypertensive rats. But RR interval,SDNN,TP,VLF and HF increased significantly with age of the moon increased in female spontaneously hypertensive rats,moreover the female SHR rats of TP,VLF and HF index of heart rate variability were lower than the male rats. Conclusion With the SHR rats age and blood pressure,blood pressure variability increased,and the female SHR rat variability in blood pressure and heart rate was significantly lower than that of the male.