期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Microparticles as Novel Biomarkers and Therapeutic Targets in Coronary Heart Disease

Microparticles as Novel Biomarkers and Therapeutic Targets in Coronary Heart Disease
原文传递
导出
摘要 INTRODUCTION Microparticles （MPs） were increased in patients with coronary heart disease （CHD）,with the subtypes and quantity of MPs variate in different types of CHD.There were emerging reports indicating that MPs may play important roles in the pathogenesis of CHD.Here in this review we summarized the pro-inflammation,pro-coagulation effects of MPs,as well as their impacts on endothelial function and angiogenesis.MPs have the potential of being powerful diagnostic biomarkers and therapeutic tools in CHD patients in the future. INTRODUCTION Microparticles （MPs） were increased in patients with coronary heart disease （CHD）,with the subtypes and quantity of MPs variate in different types of CHD.There were emerging reports indicating that MPs may play important roles in the pathogenesis of CHD.Here in this review we summarized the pro-inflammation,pro-coagulation effects of MPs,as well as their impacts on endothelial function and angiogenesis.MPs have the potential of being powerful diagnostic biomarkers and therapeutic tools in CHD patients in the future.
作者 Bo-Da Zhou Ge Guo Le-Min Zheng Ling-Yun Zu Wei Gao
机构地区 Department of Cardiology Institute of Cardiovascular Sciences and Institute of Systems Biomedicine
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第2期267-272,共6页 中华医学杂志（英文版）
基金 The study was supported by grants from the National Natural Science Foundation of China （No. 81300076） and the Beijing Natural Science Foundation （No. 7132195）.
关键词 COAGULATION Coronary Heart Disease Endothelial Function： hlflanlmation MICROPARTICLE Coagulation Coronary Heart Disease Endothelial Function： hlflanlmation Microparticle
分类号 Q513 [生物学—生物化学] S852.655 [农业科学—基础兽医学]
  • 相关文献

参考文献87

  • 1Hargett LA, Bauer NN. On the ongm of microparticles: From "platelet dust" to mediators of intercellular communication. Pulm Circ 2013;3:329-40.
  • 2Takeshita J, Mohler ER, Krishnamoorthy P, Moore J, Rogers WT, Zhang L, et al. Endothelial cell-, platelet-, and monocyte/ macrophage-derived microparticles are elevated in psoriasis beyond cardiometabolic risk factors. J Am Heart Assoc 2014;3:e000507.
  • 3Boulanger CM, Amabile N, Tedgui A. Circulating microparticles: A potential prognostic marker for atherosclerotic vascular disease. Hypertension 2006;48: 180-6.
  • 4Morel 0, Jesel L, Freyssinet JM, Toti F. Cellular mechanisms underlying the formation of circulating microparticles. Arterioscler Thromb Vase Bioi 2011;31:15-26.
  • 5Nomura S, Ozaki Y, Ikeda Y. Function and role of microparticles in various clinical settings. Thromb Res 2008;123:8-23.
  • 6Empana JP, Boulanger CM, Taffiet M, Renard 1M, Leroyer AS, Varenne 0, et al. Microparticles and sudden cardiac death due to coronary occlusion. The TIDE (Thrombus and Inflammation in sudden DEath) study. Eur Heart J Acute Cardiovasc Care 2014; Epub ahead of print.
  • 7Sinning 1M, Losch 1, Walenta K, Bohm M, Nickenig G, Werner N. Circulating CD31+/annexin V+microparticles correlate with cardiovascular outcomes. Eur Heart J 2011 ;32:2034-41. 8. Lee ST, Chu K, lung KH, Kim 1M, Moon Hl, Bahn 11, et al.
  • 8Lee ST, Chu K, lung KH, Kim 1M, Moon Hl, Bahn 11, et al. Circulating CD62E+ microparticles and cardiovascular outcomes. PLoS One 2012;7:e35713.
  • 9Biasucci LM, Porto I, Di Vito L, De Maria GL, Leone AM, Tinelli G, et al. Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circ 1 2012;76:2174-82.
  • 10Ueba T, Nomura S, Inami N, Nishikawa T, Kajiwara M, Iwata R, et al. Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men. 1 Atheroscler Thromb 2010;17:342-9.
Chinese Medical Journal
2015年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部