摘要
INTRODUCTIONKnee osteoarthritis （KOA） has many risk factors,such as overweight,old age,and female gender,[1,2] and patients with KOA are generally asked to lose weight as well as have moderate exercise.[3-5] However,up to now,it is still unclear what causes the pathological conversion from nondisease to disease.And there still remains many KOA features that without proper explanation.For example,why KOA is more common in black and Chinese people than in white people？[6] Except for the racial and ethnic differences,the former seems to eat less and do more manual labor than the latter.Furthermore,since mechanical malalignment is believed to be the most potent factor in KOA progression,[7] why some pathological changes （such as worn articular cartilage,osteophytes,bony sclerosis and cysts） happened at the edge of the bone,which are supposed to be seldom influenced by the load？ And patellofemoral joint compartments,most commonly affected by KOA is an unload-bearing joint.[6,8] There may exist some factor that act on the cartilage surface and cause these changes.
INTRODUCTIONKnee osteoarthritis （KOA） has many risk factors,such as overweight,old age,and female gender,[1,2] and patients with KOA are generally asked to lose weight as well as have moderate exercise.[3-5] However,up to now,it is still unclear what causes the pathological conversion from nondisease to disease.And there still remains many KOA features that without proper explanation.For example,why KOA is more common in black and Chinese people than in white people？[6] Except for the racial and ethnic differences,the former seems to eat less and do more manual labor than the latter.Furthermore,since mechanical malalignment is believed to be the most potent factor in KOA progression,[7] why some pathological changes （such as worn articular cartilage,osteophytes,bony sclerosis and cysts） happened at the edge of the bone,which are supposed to be seldom influenced by the load？ And patellofemoral joint compartments,most commonly affected by KOA is an unload-bearing joint.[6,8] There may exist some factor that act on the cartilage surface and cause these changes.
