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Chemoresistance to CDDP Induces EMT Through Activation of RAC1 in SKOV3 Human Ovarian Cancer Cells 被引量：2

Chemoresistance to CDDP Induces EMT Through Activation of RAC1 in SKOV3 Human Ovarian Cancer Cells
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作者 ZENG Yong XIA Kun
机构地区 The State Key Laboratory of Medical Genetics Translational Medicine Research Center of Hunan Cancer Hospital Changsha
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2015年第2期195-196,共2页 Progress In Biochemistry and Biophysics
基金 This work was supported by grants from The National Natural Science Foundation of China （81201730）, China Postdoctoral Science Foundation Grant （2012M521565）, National Basic Research Program of China （2012CB517902）, National Natural Science Foundation of China （81330027）.
关键词 生物化学 生物物理 物理研究 植物
分类号 Q5-4 [生物学—生物化学] Q6 [生物学—生物物理学]
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参考文献10

  • 1Mani S A, Guo W, Liao M J, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 2008, 133(4): 704-715.
  • 2Polyak K, Weinberg R A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cells traits. Nature Review Cancer, 2009, 9(4): 265-273.
  • 3Kalluri R, Weinberg R A. The basics of epithelial-mesenchymal transition. J Clin Invest, 2009, 119(6): 1420-1428.
  • 4Bid H K, Roberts R D, Manchanda P K, et al. RACI: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther, 2013, 12(10): 1925-1934.
  • 5Gulhati P, Bowen K A, LIU J, et ol. mTORCI and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer v/a RhoA and Racl signaling pathways. Cancer Res, 2011, 71(9): 3246-3256.
  • 6Chen X, Cheng H, Pan T, et al. mTOR regulate EMT through RhoA and Rac 1 pathway in prostate cancer. Mol Carcinog, 2014, [Epub ahead of print].
  • 7Gonzalez-villasana V, Fuentes-Mattei E, Ivan C, et al. Racl/Pakl/P38/ mmp-2 axis regulates angiogenesis in ovarian cancer. Clin Cancer Res, 2015, [Epub ahead of print].
  • 8Foster R, Buckanovich R J, RUEDA B R. Ovarian cancer stem cells: working towards the root of sternness. Cancer Lett, 2013, 338(1): 147-157.
  • 9Chen J, Wang J, Chen D, et al. Evaluation of characteristics of CD44+CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures. BMC Cell Biol, 2013, 14(14): 7.
  • 10Zhang S, Balch C, Chan M W, et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res, 2008, 68(11): 4311-4320.

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生物化学与生物物理进展
2015年 第2期

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