CIP2A在前列腺癌中的表达及临床意义

Expression of CIP2A in prostate carcinoma and its clinical implication

目的:探讨蛋白磷酸酶2A的癌性抑制因子(CIP2A)蛋白在前列腺癌中的表达及临床意义。方法:应用免疫组织化学方法对前列腺癌(65例)和良性前列腺增生(30例)标本中CIP2A蛋白表达进行检测,将CIP2A染色分数与临床病理参数进行对照研究。结果:CIP2A在前列腺癌组织中的表达较良性增生组织明显增加(P<0.01);CIP2A的表达与Gleason评分具有相关性(P<0.01);接受根治性前列腺切除术的患者,CIP2A表达与危险分级(P=0.011)相关,但CIP2A表达和PSA浓度之间无明显的相关性。结论:CIP2A蛋白在前列腺癌组织中的表达增加,其表达与肿瘤的低分化和高风险明显相关。

Objective：To investigate the expression and significance of CIP2 A protein in prostate cancer.Method：We used immunohistochemistry to study the expression of the CIP2 Aprotein in prostate cancer（n=65）and BPH（n=30）specimens.The CIP2 Astaining scores were compared with several clinicopathological parameters.Result：Compared with the benign hyperplastic epithelium,the expression of CIP2 Aincreased in prostate cancer epithelium（P〈0.01）.The expression of CIP2 A was associated with high Gleason scores（P〈0.01）.Among patients treated with radical prostatectomy,CIP2 A expression was associated with pre-treatment risk stratification（P =0.011）.There was no statistically significant association between CIP2 Aexpression and prostate specific antigen concentration.Conclusion：The expression of CIP2 Aprotein increases in prostate cancer specimens,and it＇s associated with poor differentiation and high risk of the tumors.