摘要
目的:探讨蛋白磷酸酶2A的癌性抑制因子(CIP2A)蛋白在前列腺癌中的表达及临床意义。方法:应用免疫组织化学方法对前列腺癌(65例)和良性前列腺增生(30例)标本中CIP2A蛋白表达进行检测,将CIP2A染色分数与临床病理参数进行对照研究。结果:CIP2A在前列腺癌组织中的表达较良性增生组织明显增加(P<0.01);CIP2A的表达与Gleason评分具有相关性(P<0.01);接受根治性前列腺切除术的患者,CIP2A表达与危险分级(P=0.011)相关,但CIP2A表达和PSA浓度之间无明显的相关性。结论:CIP2A蛋白在前列腺癌组织中的表达增加,其表达与肿瘤的低分化和高风险明显相关。
Objective:To investigate the expression and significance of CIP2 A protein in prostate cancer.Method:We used immunohistochemistry to study the expression of the CIP2 Aprotein in prostate cancer(n=65)and BPH(n=30)specimens.The CIP2 Astaining scores were compared with several clinicopathological parameters.Result:Compared with the benign hyperplastic epithelium,the expression of CIP2 Aincreased in prostate cancer epithelium(P〈0.01).The expression of CIP2 A was associated with high Gleason scores(P〈0.01).Among patients treated with radical prostatectomy,CIP2 A expression was associated with pre-treatment risk stratification(P =0.011).There was no statistically significant association between CIP2 Aexpression and prostate specific antigen concentration.Conclusion:The expression of CIP2 Aprotein increases in prostate cancer specimens,and it's associated with poor differentiation and high risk of the tumors.
出处
《临床泌尿外科杂志》
2015年第2期124-126,共3页
Journal of Clinical Urology