低氧诱导因子-1α与卵巢上皮癌临床病理关系的Meta分析

Relationship between hypoxia inducible factor-1α and clinicopathology of epithelial ovarian cancer:Meta analysis

目的：探讨低氧诱导因子-1α（HIF-1）在卵巢上皮癌中的表达及其与卵巢上皮癌各临床病理指标的关系,明确HIF-1在卵巢上皮癌恶性生物学行为中的作用。方法：计算机检索Cochrane Library、EMbase、Pubmed数据库以及中国学术期刊全文数据库、中国生物医学文献数据库中有关HIF-1α与卵巢上皮癌研究的文献,采用STATA 11.0软件包分析HIF-1α蛋白表达与患者年龄、病理类型、病理分级、淋巴结转移、临床分期之间的关系,采用合并优势比（OR）及95%可信区间（）进行分析。结果：最终入选6篇文献共257例卵巢上皮癌患者,结果显示HIF-1α总体阳性表达率为72.4%（186/257）,较正常组织表达明显增加（OR=0.036,95%CI：0.010~0.135,P=0.000）。HIF-1α与淋巴结转移、临床分期相关（OR=0.080,95%CI：0.029~0.220,P=0.000;OR=0.258,95%CI：0.136~0.490,P=0.000）。HIF-1α阳性表达患者易出现淋巴结转移、临床分期偏晚。HIF-1α与年龄、病理类型及病理分级无明显相关（P均〉0.05）。结论：HIF-1α蛋白表达增加了卵巢上皮癌的发病风险,HIF-1α可能作为有无淋巴结转移或临床分期的判断指标。

OBJECTIVE：To explore the expression of hypoxia inducible factor-1α （HIF-1α） in epithelial ovarian cancer and its relationship with clinical pathology,in order to understand the effect of HIF-1α in malignant biological behavior of ovarian epithelial carcinoma clear.METHODS：Original foreign literatures on the correlation between HIF-1α and epithelial ovarian cancer were selected from Cochrane Library,EMbase database,Pubmed,and Chinese original literatures were from CNKI,CBM. All analyses were performed by software STATA 11.0. Relationships between HIF-1α expression and age,pathological type,histological grade,lymph node metastasis,clinical stage were analyzed using pooled odds ratio （OR） with 95% confidence interval （CI）.RESULTS：A total of 6 papers including 257 cases of epithelial ovarian cancer were analyzed. Compared with that in normal tissue,total positive rate of HIF-1αin epithelial ovarian cancer was 72.4%,which was increased significantly （OR=0.036,95%CI：0.010-0.135,P=0.000）; HIF-1α was significantly correlated with lymph node metastasis and clinical stage（OR=0.080,95%CI：0.029-0.220,P=0.000;OR=0.258, 95%CI：0.136-0.490,P=0.000）. Patients with positive expression of HIF-1α were prone to lymph node metastasis and advanced clinical stage. HIF-1α had no significant relation with age,pathological type and pathological grading （P〉0.05）. CONCLUSION：The expression of HIF-1α protein increased the risk of epithelial ovarian cancer. HIF-1α could be used as indicator of lymph node metastasis and clinical stage.