感染/炎症在早产儿视网膜病变中的作用

Role of infection/inflammation in retinopathy of prematurity

感染/炎症是早产的重要启动因素,同时感染也是早产儿常见的并发症。近来,临床研究提示早产儿视网膜病变(retinopathy of prematurity,ROP)与新生儿或母体的感染/炎症相关;基础研究也发现炎症可影响视网膜血管的正常发育,参与调控视网膜新生血管的形成。了解感染/炎症在ROP中的可能作用,对于ROP的早期诊断和防治有重要意义。本文就感染/炎症与ROP的关系及相关的作用机制进行综述。

Infection/inflammation is an important initiate factor of preterm birth, and infection is also a common complication of premature infants. Recently, a series of clinical researches have suggested that neonatal and maternal infection/inflammation are closely associated with retinopathy of prematurity （ROP）. Furthermore, experinmn- tal studies have also shown that inflammation may interfere with normal retinal angio- genesis and participate with retinal neovascularization. To clarify the possible function of infection/inflammation in ROP plays an important role in its early diagnosis, treat- ment, and even prevention. This article reviews the role of infection/inflammation in ROP and discuss the underlying pathogenesis mechanism.