不孕与宫颈人乳头瘤病毒感染的关系研究

Ralationship between Tubal Infertility and Cervical Human Papillomavirus Infection

目的:调查不孕患者宫颈人乳头瘤病毒(HPV)的感染率及亚型分布。方法:采用快速导流杂交法对217例输卵管不孕患者和174例非输卵管不孕患者进行21种HPV亚型检测。结果:391例不孕患者的HPV阳性率为17.90%,其中输卵管不孕患者的HPV阳性率为20.28%,非输卵管不孕患者的HPV阳性率为14.94%,两组差异无统计学意义(χ2=1.869,P>0.05)。HPV阳性的不孕患者中HPV高危型占82.86%,高危型中检出率最高的是HPV 58,其次是HPV 52。输卵管不孕组和非输卵管不孕组HPV感染均以高危型为主,两组间HPV高危型感染率差异无统计学意义(χ2=1.343,P>0.05)。结论:HPV高危型感染可能是女性不孕症的危险因素之一,且HPV阳性不孕患者中绝大部分为HPV高危型。

Objective： To analyze the prevalence and subtypes of human papillomaviruses among infertile women. Methods： The genotypes of HPV infection from 217 tubal infertile women and 174 infertile women caused by problems other than oviduct were detected with Hybri Max. Results： 17. 90% of 391 infertile women were detected positive for HPV. There was no significant difference of prevalence of HPV infection between two groups of infertile women（ 20. 28% vs 14. 94%,χ^2= 1. 869,P〉 0. 05）. 82. 86% of HPV positive specimens were high risk subtypes,the most common subtypes were HPV58 and HPV52. The genotypes detected in two groups of infertile women were mainly high risk subtypes,with no significant difference（ χ^2=1. 343,P〉0. 05）. Conclusions： Infection of high risk subtypes HPV may be a risk factor for female infertility,the majority of HPV positive patients are high risk subtypes.