中性粒细胞与淋巴细胞的比值在早期糖尿病肾病患者中的变化及意义

Clinic significance of neutrophil-iymphocyte ratio in the early-stage diabetic nephropathy

目的探讨中性粒细胞与淋巴细胞的比值(NLR)在早期糖尿病肾病(DN)患者中的变化及意义。方法选取91例确诊为早期DN的患者为DN组,54例正常健康人为对照组,比较2组的中性粒细胞、淋巴细胞、NLR及生化指标水平,采用Logistic回归分析早期DN的影响因素。结果 DN组的肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、中性粒细胞、C反应蛋白(CRP)高于对照组,淋巴细胞数低于对照组(均P<0.05);DN组的NLR水平高于对照组(2.52±0.57 vs 1.82±0.60,t=6.997,P<0.01)。Logistic回归分析表明,NLR、TG、TC升高均是DN的危险因素。结论 NLR升高是早期DN的高危因素,可预测早期DN的发生。

Objective To investigate neutrophil lymphocyte ratio（NLR） in early-stage diabetic nephropathy and itsclinic significance. Methods The 145 subjects were divided into two groups： the healthy control group（n=54） and earlystage diabetic nephropathy group（n=91）. The numbers of neutrophils（N） and lymphocytes（L） as well as the NLR values ofperipheral blood and other biochemistry index were examined. Factors of early stage diabetic nephropathy were calculated us-ing variance and logistic regression analysis. Results Creatinine（Cr）, total cholesterol（TC）, triglyceride（TG）, LDL-C, neu-trophils number and CRP in DN group were significantly higher than those of the control group and lymphocytes numbers ofDN group were significantly lower than that of the control group（P〈0.05 respectively）; NLR values were significantly higherin diabetic nephropathy group compared with those of healthy control group（2.52±0.57 vs 1.82±0.60,t=6.997, P 〈0.01）. Lo-gistic regression analysis showed that the risk factors of DN include NLR, TG and total cholesterol. NLR（P 〈0.001, OR=8.951, OR 95%CI：3.595-22.287） was significantly associated with DN. Conclusion High NLR values may be a predic-tive and reliable marker ofearly-stage DN.