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microRNA let-7调控动物个体发育的研究进展 被引量：2

Progress of Animal Individual Development Regulated by microRNA Let-7
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摘要 microRNA（miRNA）是一类广泛存在于多细胞动物中的进化保守的大小为18～25nt的非编码小分子RNA，可以通过与靶基因mRNA的非编码区（3’UTR）结合导致mRNA降解，或阻断mRNA翻译而调节基因表达。let-7是在线虫中发现的具有转录后调节功能的小分子RNA，具有高度的保守性，研究发现，1et-7参与动物个体多个器官组织的发育过程。作者综述了近年来lev7参与调控脑、神经系统、心肺系统和肌肉发育等组织器官的研究成果，初步阐述了1et-7调控组织器官发育的作用机制，以期为进一步探索let-7在动物体内的功能奠定基础。 microRNAs （miRNAs） are evolutionary conserved small noncoding RNAs of 18 to 25 nt that were found in all metazoans, and it regulates gene expression by base pairing with their target mRNA,leading to mRNA cleavage or translational repression, let-7 is a small RNA mole- cule originally found in worms,and it is highly conserved and plays a vital role in posttranscrip- tional regulation. The study found that let-7 takes part in the development of organs and tissues. This review summarized the recent progresses about the function of let-7 miRNA in the develop- ment of brain, nervous system, lung and cardiovascular system, and muscle development, and elu- cidated the possible mechanism of regulating the developmental processes of animal tissues and organs. It will provide the basis for further exploring the function of let-7 miRNA in animals.
作者 赵拴平 贾玉堂 徐磊 阮永明
机构地区 安徽省农业科学院畜牧兽医研究所
出处 《中国畜牧兽医》 CAS 北大核心 2015年第2期342-346,共5页 China Animal Husbandry & Veterinary Medicine
基金 国家肉牛产业技术体系-合肥综合试验站(CARS-38) 安徽省农业科学院院长青年创新基金项目(14B0428) 安徽省农业科学院高层次人才培养及引进项目
关键词 MICRORNA LET-7 个体发育 组织器官 microRNA let-7 individual development tissue and organ
分类号 Q522 [生物学—生物化学]
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参考文献37

  • 1Reinhart B J, Slack F J, Basson M, et al. The 21-nu-eleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J]. Nature, 2000,403 ( 6772) : 901-906.
  • 2Ruby J G,Jan C,Player C,et al. Large-scale sequen- cing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans [J]. Cell, 2006,127 (6) : 1193-1207.
  • 3Pasquinelli A E, Reinhart B J, Slack F, et al. Conser- vation of the sequence and temporal expression of let- 7 heteroehronic regulatory RNA[J]. Nature, 2000, 408(6808) :86-89.
  • 4王虹,滕鸿琦,施珏平,张彦定,张明凤.let-7 microRNA调控动物器官发育的研究进展[J].生命科学,2011,23(4):364-368. 被引量：8
  • 5Caygill E E, Johnston L A. Temporal regulation of metamorphic processes in drosophila by the let-7 and miR-125 heterochronic microRNAs [J]. Curr Biol, 2008,18(13) : 943-950.
  • 6Sokol N S, Xu P, Jan Y N, et al. Drosophila let 7 microRNA is required for remodeling of the neuro- musculature during metamorphosis [J]. Genes Dev, 2008,22(12) :1591-1596.
  • 7Huang J C, Babak T,Corson T W, et al. Using ex- pression profiling data to identify human microRNA targets[J]. Nat Methods, 2007,4(12) : 1045-1049.
  • 8Johnson C D, Esquela-Kerscher A, Stefani G, et al. The let-7 microRNA represses cell proliferation path- ways in human cells[J]. Cancer Res, 2007,67 (16) : 7713-7722.
  • 9Legesse-Miller A, Elemento O, Pfau S J, et al. let-7 overexpression leads to an increased fraction of cells in G2/M,direct down-regulation of Cde34, and stabi- lization of Weel kinase in primary fibroblasts[J]. J Biol Chem ,2009,284(11) :6605-6609.
  • 10Cocklin R, Heyen J, Larry T, et al. New insight into the role of the Cde34 ubiquitin-con}ugating enzyme in cell cycle regulation via Ace2 and Sicl[J]. Genetics, 2011,187(3) :701-715.

二级参考文献74

  • 1Lee RC, Feinbaum RL, Ambms V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-54.
  • 2Bentwich I, Avniel A, Karov, Y, et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Oenet, 2005, 37(7): 766-70.
  • 3Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs. Science, 2001, 294(5543): 853-8.
  • 4Lau NC, Lim LP, Weinstein EG, et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science, 2001, 294(5543): 858-62.
  • 5Pasquinelli AE, Reinhart B J, Slack F, et al. Conservation of the sequence and temporal expression of let-7heterochronic regulatory RNA. Nature, 2000, 408(6808): 86-9.
  • 6Reinhart B J, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature, 2000, 403(6772): 901-6.
  • 7Khraiwesh B, Arif MA, Seumel GI, et al. Transcriptional control of gene expression by microRNAs. Cell, 2010, 140(1): 111-22.
  • 8Bartel DR MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-97.
  • 9Kedde M, Strasser M J, Boldajipour B, et al. RNA-binding protein Dndl inhibits microRNA access to target mRNA. Cell, 2007, 131(7): 1273-86.
  • 10Johnson CD, Esquela-Kerscher A, Stefani G, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res, 2007, 67(16): 7713-22.

共引文献13

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二级引证文献16

中国畜牧兽医
2015年 第2期

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