抗仔猪腹泻产肠毒素大肠杆菌疫苗的研究进展

Research Progress on ETEC Vaccines against Piglet Diarrhea

仔猪腹泻(piglet diarrhea)是国内外养猪业面临的一大难题,每年因此造成的经济损失十分巨大。导致仔猪腹泻的主要致病菌是产肠毒素大肠杆菌(enterotoxigenic Escherichia coli,ETEC),其致病过程依赖黏附素和肠毒素的共同作用。随着研究手段的创新,国内外学者在研制ETEC疫苗方面已取得了突破性进展。作者介绍了ETEC的致病特点,并对各类ETEC疫苗的研究进展作一综述。

Piglet diarrhea is one of the most challenging problems what swine industry has faced at home and abroad, which causes a huge economic loss annually. Enterotoxigenic Escherichia coli （ETEC） is the main pathogenic bacteria of piglet diarrhea,whose pathogenicity depends on the co-effect of adhesion and enterotoxin. As the research methods innovate,the researchers at home and abroad have got important breakthroughs in the development of ETEC vaccines. This article introduced the pathogenic characters of ETEC,and summarized the progress on the development of all kinds of vaccines against ETEC.