5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物的高效合成

Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives

在分子碘作用下,以吲哚、醛和2,2-二甲基-1,3-二噁烷-4,6-二酮为原料,通过三组分缩合反应合成了10种5-[（3-吲哚基）-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物。当催化剂的用量为5%（摩尔分数）时,30℃反应60~90 min,收率为71.4%~97.3%。此外,还探讨了分子碘的催化机理。

Ten 5- [ （indol-3-yl） -methyl ] -2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized by the three component condensation reaction of indole, aldehyde and 2,2-dimethyl-1,3-dioxane-4,6-dione using iodine as the catalyst. The results indicates that the yields range from 71.4% to 97. 3% at 30 ℃ for 60 - 90 rain using 5% molar fraction of iodine. Furthermore, a mechanism for the reaction catalyzed by iodine is proposed.