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一种新型的小动物四模态分子医学影像系统 被引量:3

A New Quad-Modality Integrated Molecular Imaging System for Small Animals
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摘要 本文介绍了一种新型的小动物四模态分子影像系统的研发。该系统集成了计算机断层成像(computed tomography,CT)、正电子发射断层成像(positron emission tomography,PET)、单光子发射计算机断层成像(single-photon emission computed tomography,SPECT)和荧光分子断层成像(fluorescence molecular tomography,FMT)四种模态。对小鼠肿瘤-炎症模型的成像结果显示,融合了各个模态的综合重建结果可以提供较单一模态更加丰富的结构、功能代谢信息。 A new quad-modality integrated molecular imaging system for small animal was invented,which integrated the modalities of computed tomography(CT),positron emission tomography(PET),single-photon emission computed tomography(SPECT) and fluorescent molecular tomography(FMT).The imaging results of mouse models of tumors and inflammation revealed that the multi-modality integrated comprehensive reconstruction can provide more structural,functional and metabolic information than the single modality.
出处 《中国医疗设备》 2015年第2期7-10,共4页 China Medical Devices
基金 国家重大科学仪器专项(2011YQ030114) 国家基础研究计划973项目(2011CB707500) 国家自然科学基金(11104058) 河北省自然科学基金(A2011201155)支持
关键词 四模态 分子医学影像 CT PET SPECT 荧光分子断层成像 图像融合 quad-modality molecular imaging CT PET SPECT fluorescent molecular tomography image integration
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参考文献6

  • 1Robert A de Kemp,Frederick H Epstein,Ciprian Catana,et al. Small-animal molecular intaging methods[J].Journal of Nuclear Medicine, 21)1t/,51:18S-32S.
  • 2Bushberg Jerrold T, Boone John, Leidholdt Edwin. The essential physics of medical imaging[M].Lippiucott Williams & Wilkins, 2011.
  • 3Beyer T,Townsend DW,Brun T,et al.A combined PET/CT scanner for clinical oncology[J].Journal of Nuclear Medicine, 2000,41:1369-1379.
  • 4S R. Cherry.Multimodality imaging:Beyond pet/ct and spect/ ct[J].Semin Nucl Med,2009,39(5):348-353.
  • 5H Zaidi,R. Prasad.Advances in multimodality molecular imaging[J].Journal of medical physics/Association of Medical Physicists of India,2009,34:122.
  • 6Yanye Lu,Ktm Yang, Kedi Zhou,et al.An integrated quad- modality molecular imaging systeut for small animals[J].Joumal of Nuclear Medicine,2014,55:1375-1379.

同被引文献75

  • 1顾延,戴克戎,裘世静,戴闽.应力降低导致关节软骨退变机理的形态学研究[J].中华骨科杂志,1995,15(9):631-633. 被引量:44
  • 2马强,高永华.骨关节炎动物模型的生化及磁共振成像研究[J].中华风湿病学杂志,2005,9(8):473-475. 被引量:13
  • 3刘献祥,李西海,周江涛.改良Hulth造模法复制膝骨性关节炎的实验研究[J].中国中西医结合杂志,2005,25(12):1104-1108. 被引量:128
  • 4Pickarski M, Hayami T, Zhuo Y, et al. Molecular changes in articular cartilage and subchondral bone in the rat anterior cmciate ligament transection and meniscectomized models of osteoarthritis [J]. BMC Musculoskelet Disord, 2011, 12: 197.
  • 5Bay-Jensen AC, Nielsen RH, Segovia-Silvestre T, et al. A microarray analysis of full depth knee cartilage of ovariectomized rats [J]. BMC Res Notes, 2011, 4: 63.
  • 6van Valburg AA, van Osch G J, van der Kraan PM, et al. Quantification of morphometric changes in murine experimental osteoarthritis using image analysis [J]. Rheumatol Int, 1996, 15(5): 181-187.
  • 7AdZes S, Mendon~a M, Santos TN, et al. Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis [J]. Arthritis Res Ther, 2014, 16(1): R10.
  • 8Wang XD, Kou XX, He DQ, et al. Progression of cartilage degradation, bone resorption and pain in rat temporo- mandibular joint osteoarthritis induced by injection of iodoacetate [J]. PLoS One, 2012, 7(9): e45036.
  • 9Siebelt M, van der Windt AE, Groen HC, et al. FK506 protects against articular cartilage collagenous extra-cellular matrix degradation[J]. Osteoarthritis Cartilage, 2014, 22(4): 591-600.
  • 10Virk MS, Conduah A, Park SH, et al. Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model [J]. Bone, 2008, 42(5): 921-931.

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