期刊文献+

沉默Livin基因表达对人肝癌HepG2细胞生物学特性的影响 被引量:2

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摘要 肝细胞癌是世界范围内年发病率位居第五的恶性肿瘤,在恶性肿瘤导致的病死率中位居第3[1]。传统的治疗手段如手术切除和化疗,其治疗效果差,并且几乎不能达到完全缓解或是治愈。
出处 《中国药物与临床》 CAS 2015年第2期176-178,共3页 Chinese Remedies & Clinics
基金 2013年山西省研究生创新基金(069) 山西医科大学第一医院院基金(01539) 山西医科大学青年基金(02201301)
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参考文献12

  • 1Caldwell S,Park SH.The epidemiology of hepatocellular cancer:from the perspectives of public health problem to tumor biology[J].J Gastroenterol,2009,44:96-101.
  • 2Sibley CR,Seow Y,Wood MJ.Novel RNA-based strategies for therapeutic gene silencing[J].Mol Ther,2010,18:466-476.
  • 3Xu W,Chang H,Qin CK,et al.Impact of cotrans-fection with livin and survivin sh RNA expression vectors on bio-logical behavior of Hep G2 Cells[J].Asian Pacific J Cancer Pre-vention,2013,14:5467-5472.
  • 4Wang R,Lin F,Wang X,et al.Silencing Livin gene expression to inhibit proliferation and enhance chemosensitivity in tumor cells[J].Cancer Gene Therapy,2008,15:402-412.
  • 5Liu H,Wang S,Sun H,et al.Inhibition of tumorigenesis and invasion of hepatocellular carcinoma by si RNA-mediated silencing of the livin gene[J].Mol Med Rep,2010,3:903-907.
  • 6Wang Z,Rao DD,Senzer N,et al.RNA interference and cancer therapy[J].Pharm Res,2011,12:2983-2995.
  • 7Kasof GM,Gomes BC.“Livin,a novel inhibitor of apoptosis protein family member,”he[J].J Biol Chemistry,2001,276:3238-3246.
  • 8Augello C,Caruso L,Maggioni M,et al.Inhibitors of apoptosis proteins(IAPs)expression and their prognostic significance in hepatocellular carcinoma[J].BMC Cancer,2009,9:125.
  • 9Wang R,Lin F,Wang X,et al.Silencing livin gene expression to inhibit proliferation and enhance chemosensitivity in tumor cells[J].Cancer Gene Ther,2008,15:402-412.
  • 10Choi J,Hwang YK,Sung KW,et al.Expression of Livin,an antiapoptotic protein,is an independent favorable prognostic factor in child acute lymphoblastic leukemia[J].Blood,2007,109(2):471-477.

二级参考文献21

  • 1陈涛,贾玉容,赵铁军,尹致良.反义寡核苷酸抑制survivin基因表达及肝癌细胞生长的研究[J].中国肿瘤生物治疗杂志,2004,11(3):187-190. 被引量:4
  • 2张华东,袁守军,陈惠鹏,田增月,韩昌明.Livin mRNA的反义核酸诱导MCF-7乳癌细胞凋亡作用(英文)[J].中国临床药理学与治疗学,2004,9(12):1353-1356. 被引量:14
  • 3叶超平,邱成志,黄种心,庄伟,吴瑞兰,李新丰.肝癌术后复发及预后与Survivin表达的关系[J].中华实验外科杂志,2006,23(7):829-830. 被引量:9
  • 4Lin J H,Deng G,HuangQ ,et al.A novel member of the inhibitor apoptosis protein family[J]. Biochem Biophys Res Commun, 2000,279( 3 ) : 820-831.
  • 5Vucic D,Stennicke H R, Pisabarro,et al. ML-IAP,a novel inhibitor of apoptosis that is preferentially expressed in human melanomas[J]. Curr-Biol, 2000, 10( 21 ): 1359-1366.
  • 6Kasnf, Gomes. Livin,a novel inhibitor of apoplosis protein family member[J]. J-Biol-Chem, 2001,276( 5 ) : 3238-3246.
  • 7Sanna M G,da Silva Correia J,Ducrey O,et al. IAP suppression of apoptosis involves distinct mechanisms: the TAKI/JNK1 signaling cascade and caspase inhibition[J]. Mol Cell Biol, 2002,22( 6 ) : 1754-1766.
  • 8Ambrosini G,Adida C,Altieri D C. A novel ant-apoptis gene,survivin,expressed in cancer and Iymphoma[J]. New Med, 1997,3(8) :917-921.
  • 9Hauser H P,Bardrof M,Pyrowolakis G,et al. A giant ubiqitin conjugating enzyme related to lAP apoptosis inhibitor[J].J Cell Biol, 1998,141 ( 6 ) : 1415-1422.
  • 10Li F,Ambrosini G,Chu E Y,et al.Control of apoptosis and mitolic spindle checkpoint by survivin[J]. Nature, 1998,396( 6711 ) : 580-588.

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