氨磺必利对老年精神分裂症临床疗效及认知功能的影响

The influence of amisulpride on clinical effect and cognitive function of senile schizophrenia

目的：探讨氨磺必利对老年精神分裂症患者临床疗效及认知功能的影响。方法将90例老年精神分裂症患者随机分为A组与B组，同期抽取健康体检退休职工45名设为对照组。A组与B组分别口服氨磺必利与利培酮治疗，观察12周。采用阳性与阴性症状量表、简明精神病量表评定临床疗效，副反应量表评定不良反应，采用威斯康星卡片分类测验评定认知功能。结果治疗后两组患者阳性与阴性症状量表及简明精神病量表评分均较治疗前显著下降（P＜0．05或0．01）。治疗12末两组患者威斯康星卡片分类测验的持续错误数、持续应答数、完成第1个分类所需应答数因子分均较治疗前显著下降（P＜0．05），但仍显著高于对照组（P＜0．05）；完成分类数因子分均较治疗前显著升高，但仍显著低于对照组（P＜0．01）。两组总体不良反应发生率比较差异无显著性（χ^2＝2．47，P＞0．05）。结论氨磺必利能显著改善老年精神分裂症患者的各种精神症状及认知功能，且安全性高，与利培酮相当。

Objective To explore the influence of amisulpride on clinical effect and cognitive function of se‐nile schizophrenia .Methods Ninety senile schizophrenics were randomly assigned to group A and B ,re‐tired employees selected from health examination in the corresponding period to control group .Group A took orally amisulpride and B did risperidone for 12 weeks .Clinical efficacy were assessed with the Positive and Negative Syndrome Scale （PANSS） and Brief Psychiatric Rating Scale （BPRS） ,adverse reactions with the Treatment Emergent Symptom Scale （TESS） ,and cognitive functions with the Wisconsin Card Sorting Test （WCST） .Results After treatment the PANSS and BPRS scores of group A and B lowered more sig‐nificantly compared with pretreatment （P〈0 .05 or 0 .01） .At the end of the 12th week the scores of group A and B on perseverative errors ,perseverative responses and responses needed to complete first category lowered more significantly compared with pretreatment （P〈 0 .05） ,but were significantly higher than those of control group （P〈0 .05）;scores on categories achieved heightened more significantly ,but were significantly lower than those of control group （P〈0 .01） .There was no significant group difference in the incidence of total adverse reactions （χ^2 =2 .47 , P〉0 .05） .Conclusion Amisulpride equivalent to risperi‐done could notably improve various kinds of mental symptoms and cognitive functions of senile schizo‐phrenics and has higher safety .