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CYP2C19基因多态性检测指导治疗反复支架内血栓形成一例 被引量：2

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摘要 患者男,76岁.因＂反复胸闷、胸痛10余年,再发加重4d＂入院.患者于10年前开始出现发作性胸闷、胸痛,疼痛位于心前区,呈闷胀样不适,不伴有反酸、嗳气、恶心、呕吐,无肩背部放射痛,每次发作持续10 min左右.胸闷、胸痛与进食、体位及活动无明显相关性,服用＂速效救心丸＂后症状可缓解,曾多次在当地医院治疗,考虑为＂冠心病,心绞痛＂,但未规律治疗,上述症状反复发作.4d前上述症状再次发作,疼痛程度较前加重,到当地医院住院治疗,行冠状动脉（冠脉）CT检查提示冠心病,三支病变,遂转入我院心脏内科住院治疗.
作者 简斌 赵继先 张涛 王娟 李炎 黎世勤 王家宁 肖俊会
机构地区 湖北医药学院附属人民医院(湖北省十堰市人民医院)心脏中心心内科三病区
出处 《中华内科杂志》 CAS CSCD 北大核心 2015年第2期147-149,共3页 Chinese Journal of Internal Medicine
关键词 反复胸闷 支架内血栓形成 CYP2C19 基因多态性 指导治疗 发作性胸闷 检测 肩背部放射痛
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献6

  • 1简斌,杨晓蕾,黄郁,张立国,张有明,喻卓.药物洗脱支架植入术后支架内血栓形成的临床分析[J].昆明医科大学学报,2012,33(12):117-120. 被引量：2
  • 2简斌,喻卓.氯吡格雷抵抗及其对策研究新进展[J].昆明医科大学学报,2012,33(2B):246-249.
  • 3任利辉,彭建军,徐雪丽,叶慧明,贾凯英.高维持量氯吡格雷对择期经皮冠状动脉介入患者术后临床效果的评价[J].中华医学杂志,2012,92(6):408-410. 被引量：4
  • 4Jeong YH, Tantry US, Park Y, et al. Pharmacodynamic effect of cilostazol plus standard clopidogrel versus double-dose clopidogrel in patients with type 2 diabetes undergoing percutaneous coronary intervention[J]. Diabetes Care, 2012, 35 ( 11 ) :2194-2197.
  • 5Pakhomov IaM. Comparative antiplatelet efficacy of prasugrel and high-dose clopidogrel in patients with coronary heart disease including acute coronary syndromes[ J ]. Kardiologiia, 2012,52 (3) :82-85.
  • 6Alexopoulos D, Galati A, Xanthopoulou I, et al. Ticagrelor versus prasugrel in acute coronary syndrome patients with high on- elopidogrel platelet reactivity following percutaneous coronary intervention: a pharmaeodynamie study[ J]. J Am Cull Cardiol, 2012,60(3) :193-199.

二级参考文献23

  • 1Angiolillo DJ,Fernandez-Ortiz A,Bemardo E,et al.Variability in individual responsiveness to clopidogrel:clinical clopidogrel:clinical implications,management and future perspectives.J Am Coll Cardiol,2007,49:1505-1516.
  • 2Gurbel PA,Bliden KP,Hayes KM,et al.The relation of dosing to clopidogrel responsiveness and the incidence of high posttreatment platelet aggregation in patients undergoing coronary stenting.J Am Coll Cardiol,2005,45:1392-1396.
  • 3Patti G,Colonna G,Pasceri V,et al.Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention:results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study.Circulation,2005,111:2099-2106.
  • 4Cuisset T,Frere C,Quilici J,et al.Benefit of a 600 mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol,2006,48:1339-1345.
  • 5Lotrionte M,Biondi-Zoccai GG,Agostoni P,et al.Meta-analysis appraising high clopidogrel loading in patients undergoing percutaneous coronary intervention. Am J Cardiol,2007,100:1199-1206.
  • 6Mehta SR,Yusuf S,Peters R J,et al.Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.Lancet,2001,358:527-533.
  • 7Steinhubl SR, Berger PB, Mann JT 3rd, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA,2002,288:2411-2420.
  • 8Angiolillo D J,Bemardo E,Sabate M,et al.Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.J Am Coll Cardiol,2007,50:1541-1547.
  • 9Matetzky S,Shenkman B,Guetta V,et al.Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation,2004,109:3171-3175.
  • 10Cuisset T,Frere C,Quilici J,et al.High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome.J Thromb Haemost,2006,4:542-549.

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中华内科杂志
2015年 第2期

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