甲型和乙型流行性感冒孕妇C反应蛋白及白细胞计数检测结果分析

C-reactive protein and white blood cell count in pregnant women with influenza A and B

目的探讨甲型和乙型流行性感冒(流感)孕妇C反应蛋白(C-reactive protein,CRP)、白细胞计数(white blood cell count,WBC)、中性粒细胞(neutrophil,NE)和中性粒细胞比率(NE%)水平变化及意义。方法 163例发热孕妇依据感染病原体分为甲型流感组52例、乙型流感组18例和普通上呼吸道感染组93例,检测3组CRP、WBC、NE和NE%水平,并比较WBC>10×109/L、NE>6.4×109/L、NE%>75%和CRP>10mg/L构成比。结果甲型流感组和乙型流感组CRP水平((26.25±11.03)、(25.34±10.89)mg/L)低于普通上呼吸道感染组((53.25±21.03)mg/L)(P<0.05),WBC、NE、NE%水平与普通上呼吸道感染组比较差异无统计学意义(P>0.05);甲型流感组WBC>10×109/L、NE>6.4×109/L、NE%>75%和CRP>10mg/L构成比分别为13.46%、21.63%、43.41%、9.82%,乙型流感组分别为5.56%、22.22%、44.44%、16.67%,普通上呼吸道感染组分别为23.66%、45.16%、61.29%、34.41%,甲型流感组和乙型流感组4项指标构成比低于普通上呼吸道感染组(P<0.05),甲型流感组WBC>10×109/L、CRP>10mg/L构成比与乙型流感组比较差异有统计学意义(P<0.05)。结论发热孕妇行C反应蛋白和WBC检测,在判断病情及指导临床用药上有一定意义。

Objective To investigate the changes of C-reactive protein（CRP）,white blood cell count（WBC）,neutrophil（NE）,and the percentage of neutrophils（NE%）level in pregnant women with influenza A and B.Methods According to the pathogens 163 patients were divided into influenza A group（n=52）,influenza B group（n=18）and common upper respiratory tract infection group（n=93）.CRP,WBC,NE and NE% were examined among three groups and to compare the constituent ratios of WBC10×10^9/L,NE6.4×10^9/L,NE% 75% and CRP10 mg/L in three groups.Results The CRP levels was（26.25±11.03）mg/L in influenza A group and（25.34±10.89）mg/L in influenza B group,significantly lower than that in common upper respiratory tract infection group（（53.25±21.03）mg/L）（P〉0.05）.The levels of WBC,NE and NE% were not significantly different in influenza A and influenza B groups from those in common upper respiratory tract infection group（P〈0.05）.The constituent ratios of WBC10×109/L,NE6.4×10^9/L,NE%75 % and CRP10mg/L were lower in influenza A group（13.46%,21.63%,43.41%,9.82%）and influenza B group（5.56%,22.22%,44.44%,16.67%）than those in common upper respiratory tract infection group（23.66%,45.16%,61.29%,34.41%）（P〈0.05）,and there were significant differences in the constituent ratios of WBC10×10^9/L and CRP10 mg/L between influenza A and influenza B groups（P〈0.05）.Conclusion Detection of CRP and WBC contributes to the diagnosis and therapy of influenza in pregnant women.