电针干预对多囊卵巢综合征患者纺锤体及卵子质量的影响

Effect of Electroacupuncture on the Spindle and Oocyte Quality in Polycystic Ovary Syndrome

目的回顾性分析电针干预对行体外受精-胚胎移植(IVF-ET)的多囊卵巢综合征(PCOS)患者卵子质量的影响。方法217例行IVF-ET的PCOS患者,按随机数字表分为电针组119例,对照组98例,均给予长方案超促排卵,电针组加用电针干预,观察两组患者纺锤体、卵子质量及妊娠结局的不同。结果电针组优质胚胎率明显高于对照组(P<0.05),并可提高临床妊娠率8.36%;纺锤体位于极体11点至1点的卵子数与HCG日E2水平及优胚率呈显著正相关(P<0.01);电针组纺锤体位于极体11点至1点的卵子数占卵子数的比例明显高于对照组(P<0.05);电针可明显降低PCOS患者Gn(促性腺激素)用量与用药时间(P<0.05)。结论证实了纺锤体与卵子质量的相关性;电针干预可以提高卵子质量,改善PCOS患者临床妊娠率。

Objective To investigate the effect of electroacupuncture （EA） on oocyte quality in patients with polycystic ovary syndrome （PCOS） undergoing in-vitro-fertilization and embryo transfer （IVF-ET）.Method Totally 217 patients with PCOS undergoing IVF-ET were randomized into two groups by the random number table, 119 patients in an EA group and 98 in a control group. In addition to the long-term ovarian hyperstimulation given to the two groups, electroacupuncture was involved in the intervention in the EA group. The spindle, quality of eggs, and pregnancy result were observed and compared.Result The high-quality embryo rate was significantly higher in the EA group than the control group （P〈0.05）, and compared to the control group, the pregnancy rate was 8.36% higher in the EA group; it’s found that the number of eggs with spindle located between 11 and 1 o’clock was in a significant positive correlation with the level of E2 on the HCG administration day and the high-quality embryo rate （P〈0.01）; the EA group had a markedly higher ratio of eggs with spindle located between 11 and 1 o’clock compared to the control group （P〈0.05）; electroacupuncture markedly reduced the dosage and duration of using Gn in the PCOS patients （P〈0.05）. Conclusion It’s proven the relation between spindle and the quality of eggs; electroacupuncture can enhance the quality of eggs and the pregnancy rate in the PCOS patients.