超高效液相色谱-串联质谱法测定烟用水基胶中邻苯二甲酸酯类化合物

Determination of Phthalate Acid Esters in Water-borne Adhesives for Cigarette by UPLC- MS / MS

建立了一种测定烟用水基胶中17种邻苯二甲酸酯类（PAEs）化合物的超高效液相色谱-串联质谱（UPLC-MS/MS）法。样品经水分散,以甲醇定容,涡旋振荡萃取。萃取液离心后,过有机相滤膜进行UPLC-MS/MS分析。通过增加延时柱的方法,排除色谱系统带入的PAEs干扰。结果表明：在0-5μg/m L范围内,方法的线性关系良好,相关系数均大于0.994,定量下限为0.010-0.479μg/g。该方法的回收率为87.6%-106.0%,相对标准偏差（RSD,n=6）为0.8%-6.2%。将该方法与YC/T 333-2010标准方法进行对比,结果显示两种方法的检测数据不存在显著性差异。方法用于烟用水基胶中17种PAEs的测定,操作简单,稳定性好。

A method for the determination of 17 phthalate acid esters（ PAEs） in water-borne adhesives for cigarette by ultra performance liquid chromatography- tandem mass spectrometry（ UPLC-MS / MS） was developed. The samples were dispersed with water and dissolved with methanol at constant volume,then extracted with a vortex mixer vigorously and centrifuged. After passed through an organic phase filter membrane,the extract was analyzed by UPLC- MS / MS. The interference of PAEs that chromatography system introduced was removed with a delay column. The results showed that,the calibration curves of 17 PAEs showed good linearities in the range of 0- 5 μg / m L,with correlation coefficients greater than 0. 994. The limits of quantitation were in the range of 0. 010-0. 479 μg / g. The recoveries ranged form 87. 6% to 106. 0% with relative standard deviations（ RSDs,n = 6） of 0. 8%- 6. 2%. Compared with YC / T 333- 2010 standard method,there was no significant difference between the data obtained by two methods. With the advantages of simplicity and stability,this method was used for the determination of 17 PAEs in water-borne adhesives.