43例儿童单纯性肠梗阻血浆内毒素水平研究

Research on the pediatric intestinal obstruction and serous endotoxemia in 43 cases

目的检测小儿不同程度肠梗阻血浆内毒素水平,探讨小儿肠梗阻程度与内毒素血症之间关系。方法以重庆医科大学附属儿童医院2011年1月至2014年5月收治儿童肠梗阻患儿(43例)及对照组腹股沟疝患儿(25例)作为研究对象,采用鲎试验检测方法分别检测不同时点对照组(n=25)、单纯不全性肠梗阻组(n=20)、单纯完全性肠梗阻未发生肠坏死组(n=23)血浆内毒素水平。结果各组血浆内毒素水平分别为:对照组(6.53±14.96)EU/mL,单纯不全性肠梗阻组治疗前后(4.40±1.15)EU/mL和(4.20±1.20)EU/mL、单纯完全性肠梗阻未发生肠坏死组手术前后(4.09±1.31)EU/mL和(3.70±1.46)EU/mL,经检验各组间差异无统计学意义。结论无腹腔感染及肠坏死的肠梗阻患儿无明显内毒素血症,与梗阻程度无明显相关性。

Objective serous endotoxin（ET）were measured to determine the relationship between serous endotoxin and different type of intestinal obstruction in children.Methods 25 inguinal hernia patients and 43 intestinal obstruction patients were classified into control group（n=25）,incomplete intestinal obstruction（n=20）and complete intestinal obstruction group without necrosis of intestine（n=23）according to degree of obstruction.Serous endotoxin were measured in different time（the day of admission,one day after admission or,preoperation and one day postoperation）,and t test is used to determine the difference between them.Results ET in different group was（6.53±14.96）,（4.40±1.15）,（4.20±1.20）,（4.09±1.31）,（3.70±1.46）EU/mL,respectively.There were no difference between each group.Conclusion ET examination suggests there is no difference between different type of intestinal obstruction in children and endotoxemia is not found in intestinal obstruction according to the results.