开心通灌颗粒治疗冠心病(心血瘀阻证)患者的临床观察

Cl inical Observation of Kaixin Tongguan Granule Treating Blood Stasis Resistance Type of Coronary Heart Disease Patients

目的观察经验方开心通灌颗粒对冠心病(心血瘀阻证)患者的中医证候及对血流变学指标、血脂和超敏C反应蛋白(hs-CRP)指标的影响。方法将患者随机分为治疗组与对照组各30例,两组患者均按照冠心病二级预防用药,治疗组加用开心通灌颗粒,疗程为4周;观察治疗组及对照组治疗前后患者临床症状、体征、血浆黏度(PV)、纤维蛋白原(FIB)、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)和hs-CRP指标变化情况。结果两组患者中医证候积分均有所改善,治疗组改善更加明显(P<0.05或P<0.01);两组患者血浆黏度、FIB、TG、TC、LDL-C和hs-CRP较治疗前明显下降,治疗组下降更加明显(P<0.05或P<0.01)。结论开心通灌颗粒能明显改善冠心病(心血瘀阻证)患者临床症状,可能通过抑制炎症介质释放,延缓或阻止动脉粥样硬化斑块的破裂,改善冠脉微循环,纠正脂质代谢紊乱,降低体内高凝状态,防止血栓形成,从而起到防治冠心病的作用。

Objective： To observe the protective effects of classic prescription-Kaixin Tongguan Granule on Traditional Chinese Medicine（TCM） syndrome,hemorrheology,lipid and hs-CRP in patients with blood stasis resistance type of coronary heart disease（CHD）. Methods： 60 patients with blood stasis resistance type of CHD were randomly divided into treatment group（n =30） and control group（n =30）,The therapy period lasted for 4weeks. Both groups were given coronary heart disease prevention medicine. The Kaixin Tongguan Granule was adopted in the treatment group. These levels variations including clinical symptoms,signs,hemorrheology（PV,FIB）,lipid（TG,TC,LDL-C）and hs-CRP were compared in two groups before and after the treatment. Results：TCM syndrome scores in both groups improved,but the treatment group improved more significantly,and the difference was statistically significant（P 〈0.05 or P 〈0.01）. Also,PV,FIB,TG,TC,LDL-C and hs-CRP in two groups decreased remarkably compared with before,these reductions were more evident in the treatment group,and the difference was statistically significant（P 〈0.05 or P 〈0.01）. Conclusion： The clinical symptoms could be improved significantly by the Kaixin Tongguan Granule taken by patients with blood stasis resistance type of CHD,possibly by inhibiting the release of inflammatory mediators,delaying or preventing atherosclerotic plaque rupture,improving coronary microcirculation,correcting lipid metabolism,lowering body hypercoagulable state,and preventing thrombosis,so as to play a role in prevention and treatment of CHD.